Pathogenic microRNA's in myeloid malignancies Journal Article


Authors: Khalaj, M.; Tavakkoli, M.; Stranahan, A. W.; Park, C. Y.
Article Title: Pathogenic microRNA's in myeloid malignancies
Abstract: Recent studies have significantly improved our understanding of the role microRNAs (miRNAs) play in regulating normal hematopoiesis. miRNAs are critical for maintaining hematopoietic stem cell function and the development of mature progeny. Thus, perhaps it is not surprising that miRNAs serve as oncogenes and tumor suppressors in hematologic malignancies arising from hematopoietic stem and progenitor cells, such as the myeloid disorders. A number of studies have extensively documented the widespread dysregulation of miRNA expression in human acute myeloid leukemia (AML), inspiring numerous explorations of the functional role of miRNAs in myeloid leukemogenesis. While these investigations have confirmed that a large number of miRNAs exhibit altered expression in AML, only a small fraction has been confirmed as functional mediators of AML development or maintenance. Herein, we summarize the miRNAs for which strong experimental evidence supports their functional roles in AML pathogenesis. We also discuss the implications of these studies on the development of miRNA-directed therapies in AML.
Keywords: cell differentiation; innate immunity; hematopoiesis; myelopoiesis
Journal Title: Frontiers in Genetics
Volume: 5
ISSN: 1664-8021
Publisher: Frontiers Media S.A.  
Date Published: 2014-11-19
Start Page: 361
Language: English
ACCESSION: BCI:BCI201500161462
DOI: 10.3389/fgene.2014.00361
PROVIDER: biosis
PMCID: PMC4237136
PUBMED: 25477897
Notes: Article -- Source: Biosis
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  1. Christopher Yongchul Park
    90 Park
  2. Mona   Khalaj
    9 Khalaj