Disseminated Pneumocystis carinii infection causing extrapulmonary organ failure: Clinical, pathologic, and immunohistochemical analysis Journal Article


Authors: Cote, R. J.; Rosenblum, M.; Telzak, E. E.; May, M.; Unger, P. D.; Cartun, R. W.
Article Title: Disseminated Pneumocystis carinii infection causing extrapulmonary organ failure: Clinical, pathologic, and immunohistochemical analysis
Abstract: Pneumocystis carinii pneumonia is an important infection in the immunocompromised host, and the rate of symptomatic infections has risen dramatically with the advent of immunosuppressive therapies and infections with the human immunodeficiency virus (HIV). However, dissemination of P. carinii is thought to be an unusual event, and it is rarely suspected of causing extrapulmonary symptomatology. We have recently examined the cases of patients with acquired immunodeficiency syndrome (AIDS) who demonstrated at autopsy extrapulmonary infection with P. carinii. Three of these patients had widespread pneumocystosis, and in one patient dysfunction in several organs could be directly attributed to effects of P. carinii, which contributed to his death. The possible factors leading to dissemination of P. carinii are discussed. We also describe the use of a newly developed monoclonal antibody to P. carinii in detecting extrapulmonary infections.
Keywords: immunohistochemistry; adult; middle aged; case report; pneumocystis pneumonia; pathology; monoclonal antibody; immunology; antibodies, monoclonal; diagnostic agent; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; opportunistic infections; multiple organ failure; opportunistic infection; pneumocystis; fungus antigen; antigens, fungal; pneumonia, pneumocystis; humans; human; male; article
Journal Title: Modern Pathology
Volume: 3
Issue: 1
ISSN: 0893-3952
Publisher: Nature Research  
Date Published: 1990-01-01
Start Page: 25
End Page: 30
Language: English
PUBMED: 2308917
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 27 January 2020 -- Source: Scopus
Citation Impact
MSK Authors
  1. Marc Rosenblum
    373 Rosenblum
  2. Richard J. Cote
    25 Cote