Treatment of infections in patients with the acquired immunodeficiency syndrome Journal Article

Authors: Armstrong, D.; Gold, J. W. M.; Dryjanski, J.; Whimbey, E.; Polsky, B.; Hawkins, C.; Brown, A. E.; Bernard, E.; Kiehn, T. E.
Article Title: Treatment of infections in patients with the acquired immunodeficiency syndrome
Abstract: The microorganisms that regularly infect patients with the acquired immunodeficiency syndrome (AIDS) have become well recognized. Most take advantage of defects in T-lymphocyte function, but others, such as Streptococcus pneumoniae and Haemophilus influenzae, take advantage of B-cell defects. Still others, such as Staphylococcus aureus and Shigella species, occur or persist for reasons that are unclear. Infections with organisms associated with hospitalization and medical procedures are also seen and should be anticipated. Among the infections taking advantage of T-cell defects, Pneumocystis carinii pneumonia is the most commonly diagnosed, but cytomegalovirus infection may be equally common. Disseminated Myobacterium avium-intracellulare infection has been found in one half of our patients at postmortem examination. The retrovirus responsible for AIDS commonly infects the central nervous system, as does Toxoplasma gondii. Although candida infections are common, dissemination is uncommon. Many of the infections respond to appropriate therapy but tend to recur when treatment is stopped. Often treatment courses must be prolonged even beyond those used in other immunocompromised hosts.
Keywords: t lymphocyte; lymphatic system; eflornithine; short survey; acquired immune deficiency syndrome; virus infection; ketoconazole; staphylococcus aureus; immune deficiency; drug therapy; cotrimoxazole; rifampicin; streptococcus pneumoniae; ganciclovir; therapy; protozoon; intravenous drug administration; oral drug administration; drug indication; amikacin; clofazimine; ethambutol; isoniazid; toxoplasma gondii; amphotericin b; haemophilus influenzae; pneumocystis carinii; parasite; clotrimazole; pyrazinamide; cycloserine; fiacitabine; shigella; human; priority journal; rifamycin; ethionamide; pentamidine isethionate; spiramycin; furazolidone
Journal Title: Annals of Internal Medicine
Volume: 103
Issue: 5
ISSN: 0003-4819
Publisher: American College of Physicians  
Date Published: 1985-11-01
Start Page: 738
End Page: 743
Language: English
DOI: 10.7326/0003-4819-103-5-738
PROVIDER: scopus
PUBMED: 2996410
Notes: Article -- Export Date: 26 October 2021 -- Source: Scopus
Citation Impact
MSK Authors
  1. Bruce Polsky
    69 Polsky
  2. Timothy E Kiehn
    100 Kiehn
  3. Arthur E Brown
    76 Brown
  4. Donald Armstrong
    240 Armstrong
  5. Edward M Bernard
    58 Bernard
  6. Jonathan W. M. Gold
    73 Gold
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