Colonic hyperplasia and hyperproliferation induced by a nutritional stress diet with four components of Western-style diet Journal Article

  


Authors: Newmark, H. L.; Lipkin, M.; Maheshwari, N.
Article Title: Colonic hyperplasia and hyperproliferation induced by a nutritional stress diet with four components of Western-style diet
Abstract: We studied the effects of specific nutritional modifications on colonic epithelial cell proliferation in mice and rats. The nutritional stress diet developed for this study was based on the AIN (American Institute of Nutrition)-76A semisynthetic diet, modified to contain four suggested risk factors of the human Western-style diet: increased fat and phosphate and decreased calcium and vitamin D content. We fed diets to mice and rats for 12 weeks beginning at 3 weeks of age. Hyperplasia developed in both sigmoid and ascending colon of mice and rats with lengthening of colonic crypts. Hyperproliferation developed in the sigmoid colon of mice and rats, and in the ascending colon of rats, with increased [3H]thymidine-labeling of epithelial cells. Thus, in colonic mucosa, the nutritional stress diet, which included risk factors of a Western-style diet, induced changes that occur in carcinogen-induced rodent models and in humans who are at increased risk for colonic neoplasia. [J Natl Cance0r Inst 82:491-196, 1990] © 1990 Oxford University Press.
Keywords: nonhuman; mouse; animal; mice; cell division; cell growth; calcium; risk factor; carcinogenesis; diet; colon cancer; vitamin d; hyperplasia; rat; epithelium cell; stress; rats; epithelium; phosphate; phosphates; colon; thymidine; rats, inbred lew; fat; nutrition; colonic diseases; dietary fats; female; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.
Journal Title: JNCI: Journal of the National Cancer Institute
Volume: 82
Issue: 6
ISSN: 0027-8874
Publisher: Oxford University Press  
Date Published: 1990-03-21
Start Page: 491
End Page: 496
Language: English
DOI: 10.1093/jnci/82.6.491
PUBMED: 2313721
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025265542&doi=10.1093%2fjnci%2f82.6.491&partnerID=40&md5=c393bd494fb57ff08cebd815643ee140
Notes: Article -- Export Date: 27 January 2020 -- Source: Scopus
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MSK Authors
  1. Martin Lipkin
    116 Lipkin
  2. Harold L. Newmark
    61 Newmark
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