Colonic hyperproliferation induced in rats and mice by nutritional-stress diets containing four components of a human Western-style diet (series 2) Conference Paper
| Authors: | Newmark, H. L.; Lipkin, M.; Maheshwari, N. |
| Title: | Colonic hyperproliferation induced in rats and mice by nutritional-stress diets containing four components of a human Western-style diet (series 2) |
| Conference Title: | An Update on Calcium: Applications for the '90s |
| Abstract: | In a previous study colonic hyperplasia and hyperproliferation were induced in mice and rats by a nutritional-stress diet, based on the AIN-76A semisynthetic diet modified to contain four suggested high-risk components of the human Western-style diet: increased fat and phosphate and decreased calcium and vitamin D contents. In this study the effect of raising calcium alone to near the median level (0.22 mg/kcal) and to a high level (1.3 mg/kcal), comparable to adult human dietary intake, was tested in mice and rats while retaining the three other high-risk components. With median calcium intake the nutritional-stress diet induced hyperproliferation of epithelial cells in colonic crypts, with increased numbers of proliferating cells in crypt columns in sigmoid colon of mice (P < 0.001) and rats (P = 0.02) and in the ascending colon of mice (P = 0.01). With high calcium intake, hyperproliferation was reduced almost to control amounts in the presence of unchanged fat, phosphate, and vitamin D. |
| Keywords: | controlled study; nonhuman; conference paper; energy intake; mouse; animal; mice; cell division; animal experiment; body weight; calcium; mice, inbred c57bl; animalia; diet; colon cancer; vitamin d; hyperplasia; rat; cell count; rats; phosphate; phosphates; colon; rats, inbred lew; fat; nutrition; fat intake; colonic diseases; dietary fats; female; priority journal; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; calcium, dietary; colonichyperproliferation; sigmoidea |
| Journal Title | American Journal of Clinical Nutrition |
| Volume: | 54 |
| Issue: | 1 Suppl. |
| Conference Dates: | 1990 Jan 21-23 |
| Conference Location: | Chantilly, VA |
| ISBN: | 0002-9165 |
| Publisher: | American Society for Nutrition |
| Date Published: | 1991-07-01 |
| Start Page: | 209S |
| End Page: | 214S |
| Language: | English |
| DOI: | 10.1093/ajcn/54.1.209S |
| PUBMED: | 2053564 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 September 2019 -- Source: Scopus |
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