Inhibition of Western-diet induced hyperproliferation and hyperplasia in mouse colon by two sources of calcium Journal Article

  


Authors: Richter, F.; Newmark, H. L.; Richter, A.; Leung, D.; Lipkin, M.
Article Title: Inhibition of Western-diet induced hyperproliferation and hyperplasia in mouse colon by two sources of calcium
Abstract: A Western-style diet containing high-fat and phosphate, and low calcium and vitamin D was fed to mice for 20 weeks. Starting at week 8, subgroups of animals received the Western-style diet supplemented by two different calcium sources: tricalcium phosphate and calcium citrate malate. Hyperproliferation (increased [3H]thymidine-labelled cells/ colonic crypt) and hyperplasia (increased total epithelial cells/crypt) developed in the sigmoid colon after 8 weeks of feeding the Western-style diet confirming previous results, and these were reversed at later periods by the addition of the two calcium sources to the Western-style diet Findings indicate that the modified colonic epithelial cell hyperproliferation and hyperplasia which have been associated with subsequent development of colonic neoplasia, are induced in mice fed a Western-style diet, and the addition of calcium to the diet inhibited their development in the colonic mucosa. © 1995 Oxford University Press.
Keywords: controlled study; nonhuman; dna synthesis; mouse; animal; mice; animal tissue; cell division; animal experiment; colonic neoplasms; calcium; diet supplementation; mice, inbred c57bl; isotope labeling; vitamin d; hyperplasia; phosphate; phosphates; colon; thymidine; oral drug administration; intestine crypt; tritium; colon mucosa; calcium phosphate; lipid diet; dietary fats; citrate calcium; sigmoid; female; priority journal; article; support, non-u.s. gov't; calcium, dietary
Journal Title: Carcinogenesis
Volume: 16
Issue: 11
ISSN: 0143-3334
Publisher: Oxford University Press  
Date Published: 1995-11-01
Start Page: 2685
End Page: 2689
Language: English
DOI: 10.1093/carcin/16.11.2685
PUBMED: 7586187
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028862510&doi=10.1093%2fcarcin%2f16.11.2685&partnerID=40&md5=ed5ba05eb5f439191f260254bf147ca6
Notes: Article -- Export Date: 28 August 2018 -- Source: Scopus
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MSK Authors
  1. Denis Heng Yan Leung
    114 Leung
  2. Martin Lipkin
    116 Lipkin
  3. Harold L. Newmark
    61 Newmark
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