Protective effects of tumor necrosis factor on murine hematopoiesis during cycle-specific cytotoxic chemotherapy Journal Article
| Authors: | Sløfrdal, L.; Warren, D. J.; Moore, M. A. S. |
| Article Title: | Protective effects of tumor necrosis factor on murine hematopoiesis during cycle-specific cytotoxic chemotherapy |
| Abstract: | Tumor necrosis factor (TNF) is a pleiotropic cytokine which exerts a wide range of effects when administered in vivo. Using a murine model, we have investigated the effect of pretreatment with 1 μg (2.6 x 104 units) per mouse of recombinant murine TNF-a on hematopoietic recovery following administration of cyclophosphamide, 5-fluorouracil, methotrexate, or vinblastine. TNF pretreatment results in enhanced regeneration of circulating neutrophils and hematopoietic progenitors, as measured by in vivo and in vitro assays, in animals given cycle-specific chemotherapeutic agents. The results may suggest that TNF affects cycle kinetics in hematopoietic progenitor cell populations, thus making these cells less prone to the cytocidal effects of the chemotherapeutic agents. As myeloablation is a frequent and often critical side effect following cancer treatment, these findings may have clinical implications. © 1990, American Association for Cancer Research. All rights reserved. |
| Keywords: | cancer chemotherapy; fluorouracil; nonhuman; methotrexate; animal cell; mouse; animal; mice; bone marrow; animal experiment; cyclophosphamide; mice, inbred balb c; vinblastine; tumor necrosis factor alpha; recombinant proteins; hematopoietic stem cells; hematopoiesis; neutrophils; leukocyte count; colony-forming units assay; intravenous drug administration; bone marrow toxicity; platelet count; tumor necrosis factor; erythrocyte count; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Cancer Research |
| Volume: | 50 |
| Issue: | 14 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 1990-07-15 |
| Start Page: | 4216 |
| End Page: | 4220 |
| Language: | English |
| PUBMED: | 2364379 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 January 2020 -- Source: Scopus |
