Radioprotection by murine and human tumor‐necrosis factor: Dose‐dependent effects on hematopoiesis in the mouse Journal Article

  


Authors: Slørdal, L.; Muench, M. O.; Warren, D. J.; Moore, M. A. S.
Article Title: Radioprotection by murine and human tumor‐necrosis factor: Dose‐dependent effects on hematopoiesis in the mouse
Abstract: Tumor‐necrosis factor (TNF) has been shown to confer significant radioprotection in murine models. Herein, we demonstrate a dose‐dependent enhancement of hematological recovery when single doses of either murine or human recombinant TNF are administered prior to irradiation. In addition to its action upon leukocytes and erythrocytes, TNF also alleviates radiation‐induced thrombocytopenia in the mouse. These effects on circulating blood constituents are further reflected in increased numbers of both primitive (CFU‐S) and more differentiated (CFU‐GM, CFU‐Mega) hematopoietic progenitors in TNF‐treated animals. This suggests that TNF exerts it radioprotective effects on a pool of primitive multi‐potential hematopoietic cells. © Munksgaard 1989
Keywords: nonhuman; comparative study; mouse; animal; mice; thrombocytopenia; animal experiment; dose-response relationship, drug; mice, inbred balb c; species specificity; tnf; tumor necrosis factor alpha; recombinant proteins; irradiation; hematopoietic stem cells; radiation-protective agents; hematopoiesis; radioisotope; colony-forming units assay; intravenous drug administration; colony forming unit gm; tumor necrosis factor; radioprotection; human; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.
Journal Title: European Journal of Haematology
Volume: 43
Issue: 5
ISSN: 0902-4441
Publisher: John Wiley & Sons  
Date Published: 1989-11-01
Start Page: 428
End Page: 434
Language: English
DOI: 10.1111/j.1600-0609.1989.tb00331.x
PUBMED: 2612616
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0024919132&doi=10.1111%2fj.1600-0609.1989.tb00331.x&partnerID=40&md5=a93884410de003a1177192d4c278397c
Notes: Review -- Export Date: 14 April 2020 -- Source: Scopus
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MSK Authors
  1. Malcolm A S Moore
    549 Moore
  2. David J. Warren
    19 Warren
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