Effect of recombinant murine tumor necrosis factor on hemopoietic reconstitution in sublethally irradiated mice Journal Article
| Authors: | Slørdal, L.; Warren, D. J.; Moore, M. A. S. |
| Article Title: | Effect of recombinant murine tumor necrosis factor on hemopoietic reconstitution in sublethally irradiated mice |
| Abstract: | Intravenous bolus administration of a single 2-μg dose of murine rTNF-α to BALB/c mice 20 h before sublethal total-body irradiation (7.5 Gy) conferred significant protection against radiation-induced leukopenia. Murine rTNF-α administration not only reduced the decline of neutrophil and total blood cell counts after radiation, but also accelerated the subsequent normalization of peripheral blood cell counts. This was accompanied by accelerated regeneration of primitive hematopoietic progenitors, as determined by the in vivo spleen CFU assay, and the in vitro assay of the more mature hematopoietic cell compartment. This demonstrates that pretreatment with murine rTNF-α enhances hematopoietic reconstitution after sublethal irradiation, and indicates a possible therapeutic potential for this agent in the treatment of radiation-induced myelosuppression. |
| Keywords: | nonhuman; mouse; animal; mice; bone marrow; bone marrow suppression; spleen; radiotherapy; animal experiment; animal model; mice, inbred balb c; tumor necrosis factor alpha; recombinant proteins; irradiation; hematopoietic system; hematopoiesis; neutrophils; leukocyte count; intravenous drug administration; injections, intravenous; tumor necrosis factor; colony forming unit; priority journal; radiation chimera; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Journal of Immunology |
| Volume: | 142 |
| Issue: | 3 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 1989-02-01 |
| Start Page: | 833 |
| End Page: | 835 |
| Language: | English |
| PUBMED: | 2913152 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
