Effects of IL-1 on hematopoietic progenitors after myelosuppressive chemoradiotherapy Journal Article
| Authors: | Laver, J.; Abboud, M.; Gasparetto, C.; Gillio, A.; Smith, C.; O'Reilly, R. J.; Moore, M. A. S. |
| Article Title: | Effects of IL-1 on hematopoietic progenitors after myelosuppressive chemoradiotherapy |
| Abstract: | Recently it has been recognized that IL-1 plays an important role in hematopoietic regulation. Administration of 5-fluorouracil (5-FU) to mice causes prolonged neutropenia. rHIL-1 injected to mice after 5-FU, accelerated the recovery of hematopoietic progenitors and blood neutrophils. The combination of rhIL-1 and rhG-CSF reduced the neutropenic period significantly. Sublethal irradiation of mice induced profound neutropenia for 3 weeks which was associated with 80% mortality. Administration of rhIL-1 20 hours prior to or 2 hours post irradiation resulted in a significantly improved survival and rapid recovery of the neutrophil count. IL-1 administered alone or in combination with other colony stimulating factors to spontaneous breast tumor bearing mice following 5-FU therapy resulted in a rapid recovery of neutrophils, improved survival, and markedly reduced the tumor mass. Experiments in primates demonstrated that rhIL-1 administered to 5-FU treated animals shortened the neutropenic period from 30 to 17 days and increased the number of marrow progenitors responsive to other CSFs. Prolonged administration of IL-1 (14 days) to these animals resulted in a delayed neutrophil recovery as compared to animals receiving short courses of IL-1. rhIL-1 administered to primates receiving marrow grafts after lethal irradiation, did not result in rapid hematopoietic recovery. In humans, studies with CD-34 positive marrow cells showed that IL-1 had a radioprotective effect on a committed and early marrow progenitors. These data show the therapeutic potential of IL-1 in the treatment of chemoradiotherapy induced myelosuppression. © 1989 Kluwer Academic Publishers. |
| Keywords: | neutropenia; fluorouracil; nonhuman; combined modality therapy; chemotherapy; animal cell; mouse; animal; mice; bone marrow cells; bone marrow; bone marrow suppression; radiation; radiotherapy; mice, inbred balb c; mice, inbred strains; breast tumor; hematopoietic stem cells; drug therapy; granulocyte colony stimulating factor; antigens, cd34; antigens, differentiation; interleukin 1; interleukin-1; macaca fascicularis; intraperitoneal drug administration; human; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; hematopoietic growth factors; marrow progenitors |
| Journal Title: | Biotherapy |
| Volume: | 1 |
| Issue: | 4 |
| ISSN: | 0921-299X |
| Publisher: | Kluwer Academic Publishers |
| Date Published: | 1989-12-01 |
| Start Page: | 293 |
| End Page: | 300 |
| Language: | English |
| DOI: | 10.1007/bf02171005 |
| PUBMED: | 2484306 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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