Progress in the ex vivo expansion of hematopoietic progenitors Journal Article


Authors: Muench, M. O.; Roncarolo, M. G.; Namikawa, R.; Bárcenat, A.; Moore, M. A. S.
Article Title: Progress in the ex vivo expansion of hematopoietic progenitors
Abstract: In this review we describe how studies on the cytokine-stimulated growth of murine bone marrow (BM) progenitors have lead to the observations that large increases in progenitor numbers can be achieved in short-term cytokine-stimulated liquid cultures. Transplantation of these ex vivo expanded murine BM cells was shown to decrease the number of BM cells required to confer radioprotection and to increase the recovery rate of both myeloid and erythroid peripheral blood cells. The ex vivo expansion of murine BM cells does not, however, markedly diminish stem cells capable of long-term hematopoietic reconstitution. Investigations on the expansion of human BM, peripheral blood, umbilical cord blood and fetal hematopoietic progenitors have demonstrated that clinically useful increases in progenitor numbers from these tissues are possible. Thus, ex vivo progenitor expansion may soon be of use in transplantation protocols to accelerate hematopoietic reconstitution and in gene therapy protocols if hematopoietic stem cells can be maintained during ex vivo culture. © 1994 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Keywords: review; nonhuman; cell proliferation; animal cell; mouse; animal; mice; bone marrow cells; cell division; bone marrow; cell growth; culture medium; stem cell; cytokine; cytokines; cell culture; hematopoietic stem cells; hematopoiesis; hematopoietic stem cell; bone marrow transplantation; fetal liver; radiation protection; human; priority journal; hematopoietic tissue; stimulation, chemical; bone marrow expansion; cytokines cord blood
Journal Title: Leukemia and Lymphoma
Volume: 16
Issue: 1-2
ISSN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 1994-12-01
Start Page: 1
End Page: 11
Language: English
DOI: 10.3109/10428199409114134
PROVIDER: scopus
PUBMED: 7696914
DOI/URL:
Notes: Export Date: 14 January 2019 -- Article -- CODEN: LELYE C2 -- Source: Scopus
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  1. Malcolm A S Moore
    549 Moore