Cerebrospinal fluid neopterin in human immunodeficiency virus type 1 infection Journal Article

  


Authors: Brew, B. J.; Bhalla, R. B.; Paul, M.; Gallardo, H.; McArthur, J. C.; Schwartz, M. K.; Price, R. W.
Article Title: Cerebrospinal fluid neopterin in human immunodeficiency virus type 1 infection
Abstract: We evaluated cerebrospinal fluid (CSF) concentrations of neopterin, a putative marker of activated macrophages, in 97 subjects infected with human immunodeficiency virus type 1 who had a spectrum of neurological complications. The highest CSF neopterin concentrations occurred in those with neurological opportunistic infections, primary central nervous systems lymphoma, and acquired immunodeficiency syndrome (AIDS) dementia complex. In general, the CSF concentration of neopterin was independent of CSF cell count and blood‐brain barrier disruption to albumin. In the patients with AIDS dementia complex, CSF neopterin concentrations correlated with severity of disease and decreased in conjunction with clinical improvement following treatment with zidovudine. These results suggest that CSF neopterin, although not disease‐specific, may be useful as a surrogate marker for the presence of AIDS dementia complex and its response to antiviral therapy. Copyright © 1990 American Neurological Association
Keywords: major clinical study; comparative study; human immunodeficiency virus infection; brain neoplasms; biological markers; cohort studies; cerebrospinal fluid; blood-brain barrier; lymphoma; headache; hiv infections; opportunistic infections; hiv-1; immunity, cellular; biopterin; human; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; neopterin; aids dementia complex
Journal Title: Annals of Neurology
Volume: 28
Issue: 4
ISSN: 0364-5134
Publisher: Wiley Blackwell  
Date Published: 1990-10-01
Start Page: 556
End Page: 560
Language: English
DOI: 10.1002/ana.410280413
PUBMED: 2252366
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025151457&doi=10.1002%2fana.410280413&partnerID=40&md5=a26285374e454929d22653df6a05a3ff
Notes: Article -- Source: Scopus
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MSK Authors
  1. Humilidad Gallardo
    63 Gallardo
  2. Morton Schwartz
    186 Schwartz
  3. Richard W. Price
    58 Price
  4. Bruce J. Brew
    19 Brew
  5. Ravi Bhalla
    19 Bhalla
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