Cerebrospinal fluid β(2) microglobulin in patients infected with human immunodeficiency virus Journal Article
| Authors: | Brew, B. J.; Bhalla, R. B.; Fleisher, M.; Paul, M.; Khan, A.; Schwartz, M. K.; Price, R. W. |
| Article Title: | Cerebrospinal fluid β(2) microglobulin in patients infected with human immunodeficiency virus |
| Abstract: | We prospectively evaluated CSF concentrations of β2 microglobulin (β2M) in 65 human immunodeficiency virus type 1 seropositive patients. The highest concentrations occurred in those with lymphoma, neurologic opportunistic infections, and acquired immune deficiency syndrome dementia complex (ADC). There was a high correlation between the CSF β2M concentration and ADC severity, suggesting that CSF β2M may be useful as a marker for the development, progression, and perhaps response to treatment of ADC. Elevated CSF β2M was not due to CSF pleocytosis and was usually independent of blood-brain barrier dysfunction. © 1989 American Academy of Neurology. |
| Keywords: | adult; major clinical study; human immunodeficiency virus infection; cerebrospinal fluid; blood-brain barrier; dementia; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; beta 2 microglobulin; human immunodeficiency virus 1; brain lymphoma; osmolar concentration; human; male; female; priority journal; beta 2-microglobulin; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Neurology |
| Volume: | 39 |
| Issue: | 6 |
| ISSN: | 0028-3878 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1989-06-01 |
| Start Page: | 830 |
| End Page: | 834 |
| Language: | English |
| PUBMED: | 2657485 |
| PROVIDER: | scopus |
| DOI: | 10.1212/wnl.39.6.830 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 14 April 2020 -- Source: Scopus |
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