Increased neopterin levels in brains of patients with human immunodeficiency virus type 1 infection Journal Article
| Authors: | Shaskan, E. G.; Brew, B. J.; Rosenblum, M.; Thompson, R. M.; Price, R. W. |
| Article Title: | Increased neopterin levels in brains of patients with human immunodeficiency virus type 1 infection |
| Abstract: | Abstract: Postmortem levels of native neopterin (D‐erythroneopterin) were measured in cerebral cortical samples from 44 human immunodeficiency virus type 1‐infected and eight uninfected, nonneurological control patients. Cerebral cortical gray and white matter neopterin levels for the controls ranged from 0.5 to 7.2 pmol/mg of protein in contrast to neopterin levels in brains of the virus‐infected patients, which frequently were more than threefold and occasionally more than 30‐fold higher than mean control levels. Cortical neopterin levels did not correlate with severity of the acquired immunodeficiency syndrome dementia complex, but subcortical levels correlated with the presence of active human immunodeficiency virus type 1 infection, as reflected by pathological evidence of multinucleated giant cell encephalitis. Evidence of opportunistic cytomegalovirus infections in ∼25% of the human immunodeficiency virus type 1‐infected patients was associated with enhanced levels of neopterin in frontal cortex. Copyright © 1992, Wiley Blackwell. All rights reserved |
| Keywords: | adult; clinical article; controlled study; human tissue; comparative study; human immunodeficiency virus infection; brain cortex; disease severity; tissue distribution; brain; reference values; dementia; human immunodeficiency virus; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; encephalitis; giant cell; cytomegalovirus infection; cytomegalovirus; neuropathology; human immunodeficiency virus 1; opportunistic infection; hiv-1; brain level; middle age; neurochemistry; cytomegalovirus infections; biopterin; osmolar concentration; trixis; human; male; female; priority journal; article; support, u.s. gov't, p.h.s.; neopterin; human immunodeficiency virus type 1; acquired immunodeficiency syndrome dementia complex |
| Journal Title: | Journal of Neurochemistry |
| Volume: | 59 |
| Issue: | 4 |
| ISSN: | 0022-3042 |
| Publisher: | Wiley Blackwell |
| Date Published: | 1992-10-01 |
| Start Page: | 1541 |
| End Page: | 1546 |
| Language: | English |
| DOI: | 10.1111/j.1471-4159.1992.tb08471.x |
| PUBMED: | 1328524 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
