Relationship and prognostic value of endogenous interferon-α, ß(2)-microglobulin, and neopterin serum levels in patients with Kaposi sarcoma and AIDS Journal Article

  


Authors: Krown, S. E.; Niedzwiecki, D.; Bhalla, R. B.; Flomenberg, N.; Bundow, D.; Chapman, D.
Article Title: Relationship and prognostic value of endogenous interferon-α, ß(2)-microglobulin, and neopterin serum levels in patients with Kaposi sarcoma and AIDS
Abstract: We investigated whether elevated serum levels of p<inf>2</inf>-microglobulin and neopterin were related to the abnormal in vivo production of interferon described in patients with human immunodeficiency virus (HIV) infection, and whether these factors might add to measurements of CD4+ T cells in predicting survival and tumor regression in patients with Kaposi sarcoma associated with AIDS. p<inf>2</inf>-Microglobulin and neopterin levels were strongly correlated (r =82), and were each significantly higher in patients with detectable serum interferon-a activity. Inverse correlations were observed between prognosis and levels of these serum products. Prediction by CD4+ T-cell count of tumor regression after treatment with interferon-a and zidovudine was improved by each of two factors: (a) the presence or absence of endogenous interferon-a activity, and (b) a combined variable reflecting relative levels of the interferon- inducible products, p<inf>2</inf>-microglobulin and neopterin. The level of p<inf>2</inf>-micro- globulin was the single best predictor of survival. When p<inf>2</inf>-microglobulin was not considered, the endogenous interferon-a variable was the best predictor of survival, and the prediction was enhanced by addition of the combined variable, or the neopterin value alone. We conclude that serologic markers, which directly or indirectly reflect activation of the endogenous interferon system, may be valuable adjuncts to CD4+ T-cell counts in assessing prognosis and selecting and evaluating treatments for patients with Kaposi sarcoma and AIDS. © 1991 Raven Press, Ltd., New York.
Keywords: adult; clinical article; nonhuman; alpha interferon; follow-up studies; biological markers; cohort studies; reference values; multivariate analysis; human immunodeficiency virus; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; beta 2 microglobulin; kaposi sarcoma; sarcoma, kaposi; regression analysis; analysis of variance; serum; lymphocyte subsets; interferon type i; hiv seropositivity; prognostic markers; biopterin; prognosis; human; male; female; article; beta 2-microglobulin; support, u.s. gov't, p.h.s.; neopterin; interferon-a; p<inf>2</inf>-microglobulin
Journal Title: JAIDS: Journal of Acquired Immune Deficiency Syndromes
Volume: 4
Issue: 9
ISSN: 1525-4135
Publisher: Lippincott Williams & Wilkins  
Date Published: 1991-09-01
Start Page: 871
End Page: 880
Language: English
PUBMED: 1895208
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0025989452&partnerID=40&md5=25abc016738126b0066858d839f065ba
Notes: Article -- Export Date: 27 September 2019 -- Source: Scopus
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MSK Authors
  1. Susan Krown
    156 Krown
  2. Donna Niedzwiecki
    61 Niedzwiecki
  3. Douglass S. Chapman
    35 Chapman
  4. Neal Flomenberg
    56 Flomenberg
  5. Ravi Bhalla
    19 Bhalla
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