Immunological variables as predictors of prognosis in patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome Journal Article
| Authors: | Vadhan-Rai, S.; Wong, G.; Gnecco, C.; Cunninaham-Rundles, S.; Krim, M.; Real, F. X.; Oettgen, H. F.; Krown, S. E. |
| Article Title: | Immunological variables as predictors of prognosis in patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome |
| Abstract: | Multivariate analysis was used to identify which of a large number of pretreatment immunological parameters correlated with therapeutic response, subsequent development of opportunistic infection, and survival from the time of diagnosis in a group of 70 patients with Kaposi's sarcoma and acquired immunodeficiency syndrome treated with recombinant leukocyte A interferon. In a logistic regression model, delayed type hypersensitivity response to one or more recall antigens and high proliferative response to Escherichia coli were significant predictors for response to recombinant leukocyte A interferon (for the model, P = 0.01). For prediction of the development of opportunistic infection, the model selected low proliferative responses to phytohemagglutinin and E. coli (P 0.001). Favorable factors predicting survival in the Cox regression model were the absence of endogenous serum interferon activity and a high proliferative response to E. coli (P 0.001). The estimated median survival for the group with endogenous serum interferon activity and low E. coli response was 12 months; the median has not yet been reached for the group with no serum interferon and a high E. coli response. We conclude that immunological parameters may be useful in predicting prognosis in patients with Kaposi's sarcoma and acquired immunodeficiency syndrome. © 1986, American Association for Cancer Research. All rights reserved. |
| Keywords: | survival; clinical article; interferon; t-lymphocytes; time factors; lymphatic system; lymphocyte activation; escherichia coli; recombinant proteins; killer cells, natural; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; kaposi sarcoma; sarcoma, kaposi; antigens, surface; immunoglobulins; delayed hypersensitivity; antigens, differentiation, t-lymphocyte; interferon type i; hypersensitivity, delayed; phytohemagglutinin; skin tests; interferons; humans; prognosis; human; priority journal; beta 2-microglobulin |
| Journal Title: | Cancer Research |
| Volume: | 46 |
| Issue: | 1 |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 1986-01-01 |
| Start Page: | 417 |
| End Page: | 425 |
| Language: | English |
| PUBMED: | 2415251 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 18 August 2021 -- Source: Scopus; Acknowledgments: We wish to thank Dr. Benjamin Koziner for analysis of T-cell subsets; Dr. Ravi Bhalla for performing β2-microglobulin assays; and Mark McClung, Sonia Dawkins, and Marc Serber for preparation of the manuscript. |
Citation Impact
MSK Authors
Related MSK Work