Kaposi's sarcoma and the acquired immune deficiency syndrome: Treatment with recombinant interferon alpha and analysis of prognostic factors Journal Article

  

Authors:	Krown, S. E.; Real, F. X.; Vadhan‐Raj, S.; Cunningham‐Rundles, S.; Krim, M.; Wong, G.; Oettgen, H. F.
Article Title:	Kaposi's sarcoma and the acquired immune deficiency syndrome: Treatment with recombinant interferon alpha and analysis of prognostic factors
Abstract:	Interferon alfa‐2a (Roferon®‐AHoffmann‐La Roche Inc. NutleyNJ) was used to treat sequential groups of patients with Kaposi's sarcoma associated with the acquired immune deficiency syndrome (AIDS). Major antitumor effects (complete or partial responses) were observed in 38% of the patients treated initially with high‐dose interferon alfa‐2a and in 17% of patients in whom the dose was increased after low‐dose treatment failed. A low dose of interferon alfa‐2a was ineffective; one patient (3%) showed a partial response. Patients whose tumors responded to interferon treatment showed a significantly lower rate of opportunistic infectionas well as a longer survival than nonresponders. The status of pretreatment immune function was important in predicting the response to interferon treatment. The implication of these findings with respect to understanding the mechanism of action of interferon and the definition of the most appropriate patients for interferon treatment are discussed. Copyright © 1986 American Cancer Society
Keywords:	adult; clinical article; alpha interferon; t-lymphocytes; cancer immunotherapy; recombinant proteins; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; kaposi sarcoma; sarcoma, kaposi; immunity; alpha2a interferon; therapy; intravenous drug administration; antigens, surface; opportunistic infection; recombinant alpha2a interferon; antigens, differentiation, t-lymphocyte; interferon type i; reticuloendothelial system; digestive system; phytohemagglutinin; concanavalin a; humans; prognosis; human; male; priority journal; pokeweed mitogen; blood and hemopoietic system
Journal Title:	Cancer
Volume:	57
Issue:	8 Suppl.
ISSN:	0008-543X
Publisher:	Wiley Blackwell
Date Published:	1986-04-15
Start Page:	1662
End Page:	1665
Language:	English
DOI:	10.1002/1097-0142(19860415)57:8+<1662::Aid-cncr2820571305>3.0.Co;2-y
PUBMED:	3081247
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0022628157&doi=10.1002%2f1097-0142%2819860415%2957%3a8%2b%3c1662%3a%3aAID-CNCR2820571305%3e3.0.CO%3b2-Y&partnerID=40&md5=323d35946869ddb509c067302de355b1
Notes:	Article -- Export Date: 18 August 2021 -- Source: Scopus; Acknowledgments: The authors thank Drs. B. Koziner and R. Bhalla for immunologic studies, C. Gnecco for assistance in statistical analysis, and Sonia Dawkins for preparation of the manuscript.

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