Mitogen-activated protein kinase inhibitors induce apoptosis and enhance the diallyl disulfide-induced apoptotic effect in human CNE2 cells Journal Article
| Authors: | Wen, J.; Xiao, C. W.; Yi, W. Z.; Ya, L. N.; Talbot, S. G.; Li, G. C.; Jian, B. X.; Xu, M. |
| Article Title: | Mitogen-activated protein kinase inhibitors induce apoptosis and enhance the diallyl disulfide-induced apoptotic effect in human CNE2 cells |
| Abstract: | In this study, we investigated whether the inhibition of endogenous phosphorylation of mitogen-activated protein kinase (MAPK) and diallyl disulfide (DADS)-induced phosphorylation of MAPKs with MAPK specific inhibitors, SB203580 and U0126 (for phospho-p38 and phospho-p42/p44, respectively), can induce or enhance apoptosis in human CNE2 nasopharyngeal carcinoma cells. Our data demonstrate that MAPK inhibitors decrease the viability of CNE2 cells, stimulate typical apoptotic morphologic changes, and enhance DADS-induced apoptosis. The present findings indicate that phosphorylation of MAPKs plays an important cytoprotective role in CNE2 cell apoptosis and the DADS-induced apoptotic process. |
| Keywords: | controlled study; human cell; cell viability; cell structure; apoptosis; cell growth; mitogen activated protein kinase inhibitor; mitogen activated protein kinase p38; antineoplastic activity; cancer cell culture; in vitro study; phosphorylation; cancer inhibition; enzyme phosphorylation; mitogen activated protein kinase 1; mitogen activated protein kinase 3; cell cycle arrest; nasopharynx carcinoma; carcinoma cell; diallyl disulfide; growth inhibition; dephosphorylation; 1,4 diamino 1,4 bis(2 aminophenylthio) 2,3 dicyanobutadiene; cne2 cell; combined effect; mitogen-activated protein kinase inhibitor; 4 (4 fluorophenyl) 2 (4 methylsulfinylphenyl) 5 (4 pyridyl)imidazole |
| Journal Title: | Journal of Health Science |
| Volume: | 54 |
| Issue: | 2 |
| ISSN: | 1344-9702 |
| Publisher: | Pharmaceutical Soc Japan |
| Date Published: | 2008-04-01 |
| Start Page: | 129 |
| End Page: | 136 |
| Language: | English |
| DOI: | 10.1248/jhs.54.129 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 17 November 2011" - "CODEN: JHSCF" - "Source: Scopus" |
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