Induction of apoptosis and transient increase of phosphorylated MAPKs by diallyl disulfide treatment in human nasopharyngeal carcinoma CNE2 cells Journal Article
| Authors: | Yi, W. Z.; Wen, J.; Jian, B. X.; Talbot, S. G.; Li, G. C.; Xu, M. |
| Article Title: | Induction of apoptosis and transient increase of phosphorylated MAPKs by diallyl disulfide treatment in human nasopharyngeal carcinoma CNE2 cells |
| Abstract: | This study was undertaken to elucidate the effect of diallyl disulfide (DADS), an oil-soluble organosulfur compound found in garlic, in suppressing human nasopharyngeal carcinoma cells. A potent increase (of at least 9-fold) in apoptotic cells has accompanied 1) a decrease in cell viability, 2) a increase of the fraction of S-phase cells by up to 63.8%, and 3) a transient increase of the phospho-p38 and phospho-p42/44 (phosphorylated p38 MAPK and phosphorylated p42/44 MAPK) in a time- and concentration-dependent manner. These results indicate that DADS can induce apoptosis in human nasopharyngeal carcinoma cells via, at least partly, S-phase block of the cell cycle, related to a rise in MAPK phosphorylation. |
| Keywords: | metabolism; cell survival; cell cycle; cell cycle s phase; apoptosis; mitogen activated protein kinase p38; drug effect; cell line, tumor; phosphorylation; blotting, western; chemistry; tumor cell line; western blotting; carcinoma; mitogen activated protein kinase 1; nasopharynx tumor; nasopharyngeal neoplasms; s phase; diallyl disulfide; allyl compound; disulfide; allyl compounds; disulfides; mitogen-activated protein kinase 1; garlic; p38 mitogen-activated protein kinases; anticancer effect; diallyl disulfide (dads); human nasopharyngeal carcinoma cne2 cells; phosphorylated mapks |
| Journal Title: | Archives of Pharmacal Research |
| Volume: | 29 |
| Issue: | 12 |
| ISSN: | 0253-6269 |
| Publisher: | Pharmaceutical Society of Korea |
| Date Published: | 2006-12-31 |
| Start Page: | 1125 |
| End Page: | 1131 |
| Language: | English |
| PUBMED: | 17225462 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 8" - "Export Date: 4 June 2012" - "CODEN: APHRD" - "Source: Scopus" |
