Effect of Allium sativum (garlic) diallyl disulfide (DADS) on human non-small cell lung carcinoma H1299 cells Journal Article
| Authors: | Cao, H.; Wen, J.; Li Nie, Y.; Xu, M. |
| Article Title: | Effect of Allium sativum (garlic) diallyl disulfide (DADS) on human non-small cell lung carcinoma H1299 cells |
| Abstract: | Abstract. This study was undertaken to elucidate the effect of diallyl disulfide from Allium sativum, an oil-soluble organosulfur compound found in garlic, in suppressing human non-small cell lung carcinoma H1299 cells. A potent increase in apoptotic cells has accompanied 1) a decrease in cell viability, 2) an increase of the fraction of G2/M-phase cells by up to 48.80 %, and 3) a transient increase of the phospho-p42/44 (phosphorylated p42/44 MAPK) in a time- and concentration-dependent manner. These results indicated that diallyl disulfide could induce apoptosis in human non-small cell lung carcinoma H1299 cells via, at least partly, G2/M-phase block of the cell cycle, related to a rise in MAPK phosphorylation. |
| Keywords: | antineoplastic agent; cytology; metabolism; cell division; apoptosis; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; enzyme activation; drug effect; cell line, tumor; phosphorylation; lung tumor; chemistry; anticarcinogenic agents; tumor cell line; lung; mitogen activated protein kinase 1; mitogen activated protein kinase 3; cell cycle g2 phase; diallyl disulfide; allyl compound; disulfide; allyl compounds; disulfides; g2 phase; mitogen-activated protein kinase 1; mitogen-activated protein kinase 3; garlic |
| Journal Title: | Tropical Biomedicine |
| Volume: | 25 |
| Issue: | 1 |
| ISSN: | 0127-5720 |
| Publisher: | Malaysian Soc Parasitology Tropical Medicine |
| Date Published: | 2008-04-01 |
| Start Page: | 37 |
| End Page: | 45 |
| Language: | English |
| PUBMED: | 18600203 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 17 November 2011" - "Source: Scopus" |
