Comparative effects of natural and synthetic diallyl disulfide on apoptosis of human breast-cancer MCF-7 cells Journal Article
| Authors: | Jun, Z.; Suzuki, M.; Xiao, J.; Wen, J.; Talbot, S. G.; Li, G. C.; Xu, M. F. |
| Article Title: | Comparative effects of natural and synthetic diallyl disulfide on apoptosis of human breast-cancer MCF-7 cells |
| Abstract: | The apoptotic effects of natural (n-) and synthetic (s-) DADS (diallyl disulfide; 3,3′-thiobisprop-1-ene) on human breast-cancer MCF-7 cells were investigated in vitro. 5-Fu (5-fluorouracil) and CTX (cyclophosphamide; Cytoxan) were used as comparative control anticancer agents. After MCF-7 cells had been treated with the drugs, cell viability, morphological change, apoptosis and changes in the cell cycle were measured. The results indicated that s- and n-DADS had similar cytotoxicities towards human breast-cancer MCF-7 cells and showed dose-dependent and time-dependent inhibitory effects. Morphological observations and flow-cytometric results showed that the four drugs (s-DADS, n-DADS, CTX and 5-Fu) induced apoptosis in MCF-7 cells to different extents. The apoptotic effects of s- and n-DADS were superior to those of 5-Fu and CTX. © 2009 Portland Press Ltd. |
| Keywords: | controlled study; unclassified drug; human cell; fluorouracil; antineoplastic agents; comparative study; flow cytometry; antineoplastic agent; cell death; cell viability; cell cycle; cell cycle s phase; cell structure; apoptosis; cyclophosphamide; cytotoxicity; drug effect; pathology; cell line, tumor; breast neoplasms; cell culture; breast tumor; tumor cell line; cell membranes; cell cycle g2 phase; cell cycle m phase; in-vitro; cell strain mcf 7; 5-fluorouracil; cell cycle g1 phase; synthesis; anticancer agent; diallyl disulfide (3,3′-thiobisprop-i-ene); garlic (allium sativum); human breast-cancer mcf-7 cell lines; anti-cancer agents; apoptotic effects; diallyl disulfide; dose-dependent; human breast; induced apoptosis; inhibitory effect; mcf-7 cells; morphological changes; morphological observations; time-dependent; sulfur compounds; natural diallyl disulfide; synthetic diallyl disulfide; allyl compound; biological product; disulfide; cancer cell destruction; cell cycle g0 phase; allium sativum; allyl compounds; biological products; disulfides |
| Journal Title: | Biotechnology and Applied Biochemistry |
| Volume: | 52 |
| Issue: | 2 |
| ISSN: | 0885-4513 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2009-02-01 |
| Start Page: | 113 |
| End Page: | 119 |
| Language: | English |
| DOI: | 10.1042/ba20070242 |
| PUBMED: | 18289126 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "CODEN: BABIE" - "Source: Scopus" |
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