Technical challenges associated with the radiolabeling of monoclonal antibodies utilizing short-lived, positron emitting radionuclides Journal Article
| Authors: | Finn, R.; Cheung, N. K. V.; Divgi, C.; St Germain, J.; Graham, M.; Pentlow, K.; Larson, S. M. |
| Article Title: | Technical challenges associated with the radiolabeling of monoclonal antibodies utilizing short-lived, positron emitting radionuclides |
| Abstract: | Many factors, both physical and chemical, affect the radiolabeling of a chemical compound. These factors add a new dimension of complexity when the labeling of monoclonal antibodies is attempted with short-lived, positron emitting radionuclides. A lack of appreciation for the unique chemical separations associated with the radionuclide incorporated into the synthetic precursor can often lead to unexpected or non-reproducible results. © 1991. |
| Keywords: | unclassified drug; conference paper; monoclonal antibody; iodine 125; iodine 131; isotope labeling; iodine 124; positron; iodine 123; priority journal; iodine 121; iodine 132 |
| Journal Title: | International Journal of Radiation Applications and Instrumentation. Part B: Nuclear Medicine and Biology |
| Volume: | 18 |
| Issue: | 1 |
| ISSN: | 0883-2897 |
| Publisher: | Elsevier, Inc. |
| Date Published: | 1991-01-01 |
| Start Page: | 9 |
| End Page: | 13 |
| Language: | English |
| DOI: | 10.1016/0883-2897(91)90040-r |
| PUBMED: | 2010313 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
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