Radiation-responsive esculin-derived molecular gels as signal enhancers for optical imaging Journal Article
| Authors: | Silverman, J. R.; Zhang, Q.; Pramanik, N. B.; Samateh, M.; Shaffer, T. M.; Sagiri, S. S.; Grimm, J.; John, G. |
| Article Title: | Radiation-responsive esculin-derived molecular gels as signal enhancers for optical imaging |
| Abstract: | Recent interest in detecting visible photons that emanate from interactions of ionizing radiation (IR) with matter has spurred the development of multifunctional materials that amplify the optical signal from radiotracers. Tailored stimuli-responsive systems may be paired with diagnostic radionuclides to improve surgical guidance and aid in detecting therapeutic radionuclides otherwise difficult to image with conventional nuclear medicine approaches. Because light emanating from these interactions is typically low in intensity and blue-weighted (i.e., greatly scattered and absorbed in vivo), it is imperative to increase or shift the photon flux for improved detection. To address this challenge, a gel that is both scintillating and fluorescent is used to enhance the optical photon output in image mapping for cancer imaging. Tailoring biobased materials to synthesize thixotropic thermoreversible hydrogels (a minimum gelation concentration of 0.12 wt %) offers image-aiding systems which are not only functional but also potentially economical, safe, and environmentally friendly. These robust gels (0.66 wt %, 900 Pa) respond predictably to different types of IRs including β- and emitters, resulting in a doubling of the detectable photon flux from these emitters. The synthesis and formulation of such a gel are explored with a focus on its physicochemical and mechanical properties, before being utilized to enhance the visible photon flux from a panel of radionuclides as detected. The possibility of developing a topical cream of this gel makes this system an attractive potential alternative to current techniques, and the multifunctionality of the gelator may serve to inspire future next-generation materials. © 2017 American Chemical Society. |
| Keywords: | radiotherapy; molecular imaging; gels; image enhancement; medical imaging; diagnosis; ionizing radiation; nuclear medicine; photons; radioisotopes; diseases; cancer imaging; self assembly; cerenkov; scintillation; hydrogels; cerenkov imaging; biobased; esculin; molecular gels; self-assembly; gelation; bio-based |
| Journal Title: | ACS Applied Materials & Interfaces |
| Volume: | 9 |
| Issue: | 49 |
| ISSN: | 1944-8244 |
| Publisher: | American Chemical Society |
| Date Published: | 2017-12-13 |
| Start Page: | 43197 |
| End Page: | 43204 |
| Language: | English |
| DOI: | 10.1021/acsami.7b15548 |
| PROVIDER: | scopus |
| PUBMED: | 29135224 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 2 January 2018 -- Source: Scopus |
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