Alpha-emitting radionuclides: Current status and future perspectives Review

   


Authors: Miederer, M.; Benešová-Schäfer, M.; Mamat, C.; Kästner, D.; Pretze, M.; Michler, E.; Brogsitter, C.; Kotzerke, J.; Kopka, K.; Scheinberg, D. A.; McDevitt, M. R.
Review Title: Alpha-emitting radionuclides: Current status and future perspectives
Abstract: The use of radionuclides for targeted endoradiotherapy is a rapidly growing field in oncology. In particular, the focus on the biological effects of different radiation qualities is an important factor in understanding and implementing new therapies. Together with the combined approach of imaging and therapy, therapeutic nuclear medicine has recently made great progress. A particular area of research is the use of alpha-emitting radionuclides, which have unique physical properties associated with outstanding advantages, e.g., for single tumor cell targeting. Here, recent results and open questions regarding the production of alpha-emitting isotopes as well as their chemical combination with carrier molecules and clinical experience from compassionate use reports and clinical trials are discussed. © 2024 by the authors.
Keywords: overall survival; review; bone metastasis; positron emission tomography; technetium 99m; iodine 131; biological activity; radioactivity; tumor cell; nuclear medicine; iodine 124; radioisotope; radiation safety; bone remodeling; melanocortin 1 receptor; drug delivery system; somatostatin; antibody labeling; alpha radiation; single photon emission computed tomography; gamma radiation; actinium 225; actinium-225; bismuth 212; ion therapy; enthalpy; lutetium 177; radium 226; lead 212; human; alpha emitter; theranostic; high let; targeted alpha therapy
Journal Title: Pharmaceuticals
Volume: 17
Issue: 1
ISSN: 1424-8247
Publisher: MDPI  
Date Published: 2024-01-01
Start Page: 76
Language: English
DOI: 10.3390/ph17010076
PROVIDER: scopus
PMCID: PMC10821197
PUBMED: 38256909
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183389926&doi=10.3390%2fph17010076&partnerID=40&md5=8a4b2fd0e0298929a8148126b7a1ce51
Notes: Review -- Source: Scopus
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  1. Michael R Mcdevitt
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  2. David Scheinberg
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