Intraperitoneal chemotherapy: Analysis of complications with an implanted subcutaneous port and catheter system Journal Article
| Authors: | Davidson, S. A.; Rubin, S. C.; Markman, M.; Jones, W. B.; Hakes, T. B.; Reichman, B.; Almadrones, L.; Chapman, D.; Lewis, J. L. Jr; Hoskins, W. J. |
| Article Title: | Intraperitoneal chemotherapy: Analysis of complications with an implanted subcutaneous port and catheter system |
| Abstract: | To determine the morbidity associated with delivery of intraperitoneal chemotherapy via subcutaneous semipermanent infusion catheters, we analyzed the data on 227 patients treated from April 1985 through December 1989. A total of 249 catheters were inserted and used to administer chemotherapy in these patients. There were 40 (17.6%) complications associated with the use of 230 original catheters, with 20 patients experiencing catheter inflow obstruction and 20 developing catheter-related infections; the latter group included 8 patients with bowel perforations. Although there was a trend toward an increase in catheter-related infections in association with large bowel surgery and appendectomies, sample size limited statistical analysis. There were 7 (36.8%) complications associated with the use of 19 replacement catheters. This rate was significantly increased (P = 0.03) when compared with the complication rate of original catheters. This system functions well and has an acceptable level of morbidity for delivery of intraperitoneal chemotherapy in gynecologic cancer patients. © 1991. |
| Keywords: | controlled study; retrospective studies; major clinical study; cisplatin; fluorouracil; side effect; cytarabine; antineoplastic agent; carboplatin; interleukin 2; infection; ovary cancer; etoposide; morbidity; gamma interferon; folinic acid; mitoxantrone; catheterization; drug administration; epidemiology; floxuridine; equipment failure; intestines; catheters, indwelling; tumor necrosis factor; catheter; intraperitoneal drug administration; injections, intraperitoneal; human; female; priority journal; article; support, non-u.s. gov't; wounds, penetrating |
| Journal Title: | Gynecologic Oncology |
| Volume: | 41 |
| Issue: | 2 |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1991-05-01 |
| Start Page: | 101 |
| End Page: | 106 |
| Language: | English |
| DOI: | 10.1016/0090-8258(91)90266-8 |
| PUBMED: | 2050300 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 September 2019 -- Source: Scopus |
