Low risk of complications associated with the fenestrated peritoneal catheter used for intraperitoneal chemotherapy in ovarian cancer Journal Article

  

Authors:	Black, D.; Levine, D. A.; Nicoll, L.; Chou, J. F.; Iasonos, A.; Brown, C. L.; Sonoda, Y.; Chi, D. S.; Leitao, M. M.; Abu-Rustum, N. R.; Ferguson, S. E.; Barakat, R. R.
Article Title:	Low risk of complications associated with the fenestrated peritoneal catheter used for intraperitoneal chemotherapy in ovarian cancer
Abstract:	Objectives: We previously reported a 10% rate of catheter complications, including inflow obstruction and infection, using a fenestrated catheter to administer intraperitoneal (IP) chemotherapy for ovarian cancer. Because of recent reports of higher rates of catheter complications, we performed this study to update our experience with the fenestrated catheter. Methods: We reviewed the medical records of all patients who had a fenestrated catheter placed at our institution from 5/97-5/06. Data were collected regarding patient demographics, surgical procedure, timing of catheter insertion, and reasons for discontinuing IP chemotherapy. Results: We identified 342 patients who had fenestrated catheters placed and for whom follow-up data were available. Nine patients (3%) required discontinuation of chemotherapy due to catheter complications. Three patients experienced catheter infection, 5 patients had inflow obstruction, and 1 patient's port could not be accessed. Seventy-one patients (21%) discontinued IP chemotherapy for reasons unrelated to the catheter. The percentage of patients who completed the intended chemotherapy regimen was similar for patients who underwent a bowel resection (22/30 [73%]) compared to those who had not (226/312 [72%]) (P = 1.0). Conclusions: The fenestrated catheter for IP chemotherapy continues to be associated with a low risk of catheter-related complications. The low rate of complications, even in the setting of bowel resection and increase in utilization during upfront chemotherapy, suggest that the fenestrated catheter is still a feasible method for the administration of IP chemotherapy. © 2007 Elsevier Inc. All rights reserved.
Keywords:	adolescent; adult; cancer chemotherapy; aged; aged, 80 and over; middle aged; retrospective studies; major clinical study; fluorouracil; drug withdrawal; monotherapy; antineoplastic agents; paclitaxel; chemotherapy; cancer staging; antineoplastic agent; neoplasm staging; ovarian cancer; ovarian neoplasms; ovary cancer; allergy; kidney disease; neuropathy; dehydration; catheterization; nausea and vomiting; platinum; metabolic disorder; wound dehiscence; infusions, parenteral; catheters, indwelling; health hazard; catheter complication; intraperitoneal catheter; peritoneal catheter
Journal Title:	Gynecologic Oncology
Volume:	109
Issue:	1
ISSN:	0090-8258
Publisher:	Elsevier Inc.
Date Published:	2008-04-01
Start Page:	39
End Page:	42
Language:	English
DOI:	10.1016/j.ygyno.2007.12.004
PUBMED:	18234300
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-40949110447&partnerID=40&md5=44adcbff516a6aabc317618f58c79589
Notes:	--- - "Cited By (since 1996): 5" - "Export Date: 17 November 2011" - "CODEN: GYNOA" - "Source: Scopus"

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