Taurolidine is effective in the treatment of central venous catheter-related bloodstream infections in cancer patients Journal Article
| Authors: | Koldehoff, M.; Zakrzewski, J. L. |
| Article Title: | Taurolidine is effective in the treatment of central venous catheter-related bloodstream infections in cancer patients |
| Abstract: | Taurolidine is an antimicrobial agent that was originally used in the local treatment of peritonitis and was shown to be effective in the prevention of catheter-related bloodstream infections (CR-BSI). In this pilot study, we used taurolidine solution as an intravenous (i.v.) lock into the totally implantable intravascular devices of 11 consecutive oncological patients with catheter-related bloodstream infections not responding to systemic antimicrobial chemotherapy. All patients recovered completely from the infection. No adverse drug effects were seen. Three patients were successfully retreated for a recurrent infection. Our data suggest a beneficial role of taurolidine i.v. lock for the therapy of catheter-related bloodstream infections in oncological patients. Taurolidine i.v. lock application is feasible and could especially be useful in infections resistant to antibiotic chemotherapy. © 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved. |
| Keywords: | adult; clinical article; treatment outcome; aged; antibiotic therapy; clinical trial; drug efficacy; hypertension; cancer patient; treatment; neoplasms; infection; blood toxicity; recurrent infection; prosthesis-related infections; antiinfective agent; pilot projects; escherichia coli; ciprofloxacin; open study; solutions; bacteremia; gentamicin; staphylococcus aureus; vancomycin; metronidazole; acinetobacter baumannii; ceftriaxone; pseudomonas aeruginosa; cefazolin; anti-infective agents; catheterization, central venous; sultamicillin; pseudomonas; stenotrophomonas maltophilia; ceftazidime; imipenem; staphylococcus; intravenous catheter; piperacillin; taurine; tazobactam; humans; human; male; female; priority journal; article; antimicrobial lock solution; bloodstream infections; taurolidine; totally implantable intravascular devices; catheter related bloodstream infection; thiadiazines |
| Journal Title: | International Journal of Antimicrobial Agents |
| Volume: | 24 |
| Issue: | 5 |
| ISSN: | 0924-8579 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2004-11-01 |
| Start Page: | 491 |
| End Page: | 495 |
| Language: | English |
| DOI: | 10.1016/j.ijantimicag.2004.06.006 |
| PROVIDER: | scopus |
| PUBMED: | 15519483 |
| DOI/URL: | |
| Notes: | Int. J. Antimicrob. Agents -- Cited By (since 1996):44 -- Export Date: 16 June 2014 -- CODEN: IAAGE -- Source: Scopus |
