A prospective, randomized evaluation of the effect of silver impregnated subcutaneous cuffs for preventing tunneled chronic venous access catheter infections in cancer patients Journal Article
| Authors: | Groeger, J. S.; Lucas, A. B.; Coit, D.; LaQuaglia, M.; Brown, A. E.; Turnbull, A.; Exelby, P. |
| Article Title: | A prospective, randomized evaluation of the effect of silver impregnated subcutaneous cuffs for preventing tunneled chronic venous access catheter infections in cancer patients |
| Abstract: | Objective: This study was performed to evaluate the effect of a silver-impregnated cuff on the incidence of catheter-related bacteremia/fungemia or tunnel tract infection in cancer patients with chronic dual-lumen tunneled venous access catheters. Summary Background Data: Infection is a frequent and potentially life-threatening complication of tunneled chronic cuffed silastic central venous access catheters in cancer patients. Recent experience with antimicrobial silver-impregnated cuffs placed on nontunneled percutaneously inserted central venous catheters suggests that such a cuff may render the catheter less prone to infection. Methods: The authors prospectively randomized 200 cancer patients to receive either a dual-lumen 10 French tunneled cuffed silastic central venous access catheter or the same catheter with a second more proximal subcutaneous silver-impregnated cuff. All patients then were followed prospectively for infectious morbidity until the device was removed or the patient died. Results: The hazard rate for infection/day (95% confidence limits) was 0.0022 (0.0015 to 0.0030) for standard catheters compared with 0.0027 (0.0019 to 0.0037) for catheters with silverimpregnated cuffs (p = not significant). Regression analysis of infection-free interval of both catheter types shows no difference over the lifetime of catheter as well as the over the first 48 days after insertion. Conclusions: The study indicated no effect of a silver-impregnated cuff in decreasing the incidence of catheter-related bacteremias/fungemias, tunnel infections, or the spectrum of causative microorganisms involved in cancer patients with tunneled chronic venous access catheters. |
| Keywords: | adolescent; adult; controlled study; major clinical study; cancer patient; prospective studies; neoplasms; chronic disease; bacteremia; infection prevention; home care; catheter infection; bacterial infections; central venous catheter; middle age; catheterization, central venous; mycoses; silver; central venous catheterization; fungemia; human; priority journal; article |
| Journal Title: | Annals of Surgery |
| Volume: | 218 |
| Issue: | 2 |
| ISSN: | 0003-4932 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 1993-08-01 |
| Start Page: | 206 |
| End Page: | 210 |
| Language: | English |
| DOI: | 10.1097/00000658-199308000-00014 |
| PUBMED: | 8343002 |
| PROVIDER: | scopus |
| PMCID: | PMC1242932 |
| DOI/URL: | |
| Notes: | Source: Scopus |
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