Reducing infections associated with central venous catheters Journal Article

  


Authors: Gulati, S. C.; Acaba, L.
Article Title: Reducing infections associated with central venous catheters
Abstract: Central venous catheters (CVCs) are being used with increasing frequency. A major complication of their use is catheter-related septicemia, with a reported incidence as high as 18%. Several factors, including type of catheter and site of insertion, affect the rate of catheter-related infection. Attempts at reducing the incidence of infections have had variable results. In this issue Modak and Sampath describe a novel CVC impregnated with silver sulfadiazine and chlorhexidine. In a study in rats, the investigators demonstrated in vitro synergy of these 2 compounds against bacteria and, very importantly, against fungi. In vitro inhibition persisted even after 2 years of aging the catheter at room temperature. They also observed minimal development of bacterial resistance. This was in marked contrast to use of antibiotics, which resulted in a 40- to 100-fold increase in resistance.
Keywords: colonization; bacterial; catheter, central venous; catheter complications; silver sulfadiazine
Journal Title: Complications in Surgery
Volume: 11
Issue: 6
ISSN: 1053-749X
Publisher: SCP Communications  
Date Published: 1992-06-01
Start Page: 19
End Page: 20
Language: English
ACCESSION: WOS:A1992JA68000001
PROVIDER: wos
Notes: Source: Wos