The role of botulinum toxin type A in the radiation fibrosis syndrome: A preliminary report Journal Article

  


Authors: Stubblefield, M. D.; Levine, A.; Custodio, C. M.; Fitzpatrick, T.
Article Title: The role of botulinum toxin type A in the radiation fibrosis syndrome: A preliminary report
Abstract: Stubblefield MD, Levine A, Custodio CM, Fitzpatrick T. The role of botulinum toxin type A in the radiation fibrosis syndrome: a preliminary report. Objective: To describe the use of botulinum toxin type A (BTX-A) in radiation fibrosis syndrome (RFS). Design: Retrospective case series. Setting: A large tertiary care cancer center. Participants: Twenty-three consecutive patients treated for sequelae of RFS with BTX-A. Interventions: Not applicable. Main Outcome Measures: A description of the components of RFS thought to benefit from BTX-A injections and the patient's self-report of benefit from those injections. Results: The sequelae of RFS for which BTX-A injection was thought to be indicated include radiation-induced cervical dystonia in 18 (78%), trigeminal nerve or cervical plexus neuralgia in 10 (43%), trismus in 7 (30%), migraine in 3 (13%), and thoracic pain in 1 (4%) patient. Most (87%) patients self-reported benefit from the injections. Conclusions: Initial clinical experience with the use of BTX-A as adjunctive treatment for select neuromuscular and musculoskeletal complications of RFS in a variety of cancer patients has been encouraging. Well-designed prospective studies are needed to clarify the potential beneficial role of BTX-A in specific sequelae of RFS. © 2008 American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation.
Keywords: clinical article; treatment outcome; retrospective studies; drug efficacy; cancer radiotherapy; follow-up studies; neoplasms; infection; pain; cohort studies; bleeding; radiotherapy dosage; opiate; radiation injury; risk assessment; fibrosis; dysphagia; radiation injuries; muscle weakness; occupational therapist; pain measurement; rehabilitation; trismus; sternocleidomastoid muscle; injection site; gabapentin; tricyclic antidepressant agent; muscle relaxant agent; forehead; antiinflammatory agent; injections, intramuscular; trigeminus neuralgia; botulinum toxin a; botulinum toxin type a; neuromuscular blocking; dysarthria; trigeminal neuralgia; dystonia; myofibrosis; trapezius muscle; fibrosis, radiation; masseter muscle; muscle tightness; trigeminal nerve; muscle spasticity; torticollis
Journal Title: Archives of Physical Medicine and Rehabilitation
Volume: 89
Issue: 3
ISSN: 0003-9993
Publisher: W.B. Saunders Co.  
Date Published: 2008-03-01
Start Page: 417
End Page: 421
Language: English
DOI: 10.1016/j.apmr.2007.11.022
PUBMED: 18295617
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-39449125007&partnerID=40&md5=ae8db2dc46c48d5e7da4c5a056c48d86
Notes: --- - "Cited By (since 1996): 4" - "Export Date: 17 November 2011" - "CODEN: APMHA" - "Source: Scopus"
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MSK Authors
  1. Christian M Custodio
    25 Custodio
  2. Michael Stubblefield
    52 Stubblefield
  3. Teresa Willis Fitzpatrick
    3 Fitzpatrick
  4. Amanda Levine
    2 Levine
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