Radiation fibrosis syndrome: Neuromuscular and musculoskeletal complications in cancer survivors Journal Article
| Author: | Stubblefield, M. D. |
| Article Title: | Radiation fibrosis syndrome: Neuromuscular and musculoskeletal complications in cancer survivors |
| Abstract: | Radiation-induced toxicity is a major cause of long-term disability after cancer treatment. Radiation fibrosis describes the insidious pathologic fibrotic tissue sclerosis that can occur in response to radiation exposure. Radiation fibrosis syndrome describes the myriad clinical manifestations of progressive fibrotic tissue sclerosis resulting from radiation treatment. Radiation-induced damage can include "myelo-radiculo-plexo-neuro-myopathy," causing muscle weakness and dysfunction and contributing to neuromuscular injury. Similarly, radiation damage to neuromuscular structures contributes to radiation-induced trismus and cervical dystonia in head and neck cancer survivors. This narrative review discusses the pathophysiology, anatomy, evaluation, and treatment of neuromuscular, musculoskeletal, and functional disorders that can result as late effects of radiation treatment. Rehabilitation medicine physicians with extensive training in neuromuscular and musculoskeletal medicine as well as in the principles of functional restoration are uniquely positioned to help lead efforts to improve the quality of life for cancer survivors with radiation fibrosis syndrome. © 2011 American Academy of Physical Medicine and Rehabilitation. |
| Keywords: | range of motion; histopathology; intensity modulated radiation therapy; cancer radiotherapy; neoplasms; computer assisted tomography; pain; opiate; risk factors; cancer survivor; hypoxia; fibrosis; syndrome; radiation injuries; physician; weakness; anthracycline; muscle spasm; neuropathic pain; trismus; musculoskeletal disease; autonomic neuropathy; sternocleidomastoid muscle; cardiomyopathy; neuromuscular disease; musculoskeletal diseases; disability evaluation; acidification; botulinum toxin; shoulder pain; tendinitis; neuromuscular diseases; brain atherosclerosis; cervical dystonia; cervicobrachial neuralgia; electromyogram; myeloradiculopathy; radiation fibrosis syndrome; rotator cuff injury |
| Journal Title: | PM&R |
| Volume: | 3 |
| Issue: | 11 |
| ISSN: | 1934-1482 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2011-11-01 |
| Start Page: | 1041 |
| End Page: | 1054 |
| Language: | English |
| DOI: | 10.1016/j.pmrj.2011.08.535 |
| PROVIDER: | scopus |
| PUBMED: | 22108231 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 3 January 2012" - "Source: Scopus" |
