HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal Journal Article
| Authors: | Szabo, A.; Dalmau, J.; Manley, G.; Rosenfeld, M.; Wong, E.; Henson, J.; Posner, J. B.; Furneaux, H. M. |
| Article Title: | HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal |
| Abstract: | A neuronal antigen (HuD) recognized by the sera of patients with antibody-assoclated paraneoplastic encephalomyelitis has been isolated by screening a λ cerebellar expression library. The recombinant antigen provides an unambiguous assay for this rare condition associated with small cell lung cancer. The recombinant antigen has been used to identify specific infiltrating lymphocytes in tumors and affected brain tissues of patients with antibody-associated paraneoplastic encephalomyelitis and sensory neuronopathy. HuD mRNA is uniquely expressed in brain tissue. The HuD protein shows a remarkable homology to the Drosophila proteins Elav and Sex-lethal and is likely to play a role in neuron-specific RNA processing. © 1991. |
| Keywords: | controlled study; human tissue; animal; sensory neuropathy; gene expression; lung neoplasms; nerve tissue proteins; drosophila; cloning, molecular; rna-binding proteins; lung small cell cancer; amino acid sequence; molecular sequence data; antigen; antigens, neoplasm; recombinant fusion proteins; brain; rna, messenger; recombinant protein; ribonucleoproteins; base sequence; sequence homology, nucleic acid; paraneoplastic syndrome; rna processing; lymphocytes; carcinoma, small cell; encephalomyelitis; paraneoplastic syndromes; human; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s. |
| Journal Title: | Cell |
| Volume: | 67 |
| Issue: | 2 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 1991-10-18 |
| Start Page: | 325 |
| End Page: | 333 |
| Language: | English |
| DOI: | 10.1016/0092-8674(91)90184-z |
| PUBMED: | 1655278 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 September 2019 -- Source: Scopus |
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