How did we get there? The progression from ductal carcinoma in situ to invasive ductal carcinoma Review


Authors: Dessources, K.; Sebastiao, A. P. M.; Pareja, F.; Weigelt, B.; Reis-Filho, J. S.
Review Title: How did we get there? The progression from ductal carcinoma in situ to invasive ductal carcinoma
Abstract: Purpose of Review: Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Despite numerous studies investigating the progression from in situ to invasive disease, there is still controversy as to the mechanisms by which a DCIS comes to become an invasive cancer. Here, we reviewed the state-of-the-art of the pathologic and molecular characterization of DCIS. Recent Findings: DCIS displays intra-lesion genetic heterogeneity. Single-cell sequencing studies have demonstrated that progression from DCIS to invasive breast cancer is a complex phenomenon, which can vary from lesion to lesion. While in some DCIS, multiple clones have the ability to invade, in others, clonal selection likely takes place. Summary: The fact that DCIS displays intra-lesion genetic heterogeneity and that progression varies from patient to patient poses formidable challenges for the development of biomarkers to define the risk of progression to invasive breast cancer. © 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Keywords: evolution; progression; invasive ductal carcinoma; dcis; single-cell sequencing
Journal Title: Current Breast Cancer Reports
Volume: 11
Issue: 3
ISSN: 1943-4588
Publisher: Springer  
Date Published: 2019-09-01
Start Page: 175
End Page: 184
Language: English
DOI: 10.1007/s12609-019-00318-2
PROVIDER: scopus
DOI/URL:
Notes: Review -- Export Date: 1 October 2019 -- Source: Scopus
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  1. Britta Weigelt
    640 Weigelt