How did we get there? The progression from ductal carcinoma in situ to invasive ductal carcinoma Review
| Authors: | Dessources, K.; Sebastiao, A. P. M.; Pareja, F.; Weigelt, B.; Reis-Filho, J. S. |
| Review Title: | How did we get there? The progression from ductal carcinoma in situ to invasive ductal carcinoma |
| Abstract: | Purpose of Review: Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Despite numerous studies investigating the progression from in situ to invasive disease, there is still controversy as to the mechanisms by which a DCIS comes to become an invasive cancer. Here, we reviewed the state-of-the-art of the pathologic and molecular characterization of DCIS. Recent Findings: DCIS displays intra-lesion genetic heterogeneity. Single-cell sequencing studies have demonstrated that progression from DCIS to invasive breast cancer is a complex phenomenon, which can vary from lesion to lesion. While in some DCIS, multiple clones have the ability to invade, in others, clonal selection likely takes place. Summary: The fact that DCIS displays intra-lesion genetic heterogeneity and that progression varies from patient to patient poses formidable challenges for the development of biomarkers to define the risk of progression to invasive breast cancer. © 2019, Springer Science+Business Media, LLC, part of Springer Nature. |
| Keywords: | evolution; progression; invasive ductal carcinoma; dcis; single-cell sequencing |
| Journal Title: | Current Breast Cancer Reports |
| Volume: | 11 |
| Issue: | 3 |
| ISSN: | 1943-4588 |
| Publisher: | Springer |
| Date Published: | 2019-09-01 |
| Start Page: | 175 |
| End Page: | 184 |
| Language: | English |
| DOI: | 10.1007/s12609-019-00318-2 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 October 2019 -- Source: Scopus |
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