Ductal carcinoma in situ: Morphology-based knowledge and molecular advances Journal Article

  


Authors: Ross, D. S.; Wen, Y. H.; Brogi, E.
Article Title: Ductal carcinoma in situ: Morphology-based knowledge and molecular advances
Abstract: Ductal carcinoma in situ (DCIS) is an established precursor of invasive breast carcinoma. Immunoperoxidase stains for selected markers can assist pathologists in the diagnosis of challenging ductal epithelial proliferations, but they cannot replace morphologic evaluation as the primary and critical assessment of this disease. Molecular studies provide further insight into how DCIS progresses to invasive carcinoma and also confirm the heterogeneity of this lesion. Morphology-based knowledge, immunohistochemistry, and molecular advances in DCIS are the subjects of this review. Copyright © 2013 by Lippincott Williams & Wilkins.
Keywords: immunohistochemistry; protein expression; review; cancer radiotherapy; cancer grading; ki 67 antigen; cell proliferation; mitosis; phenotype; genetic predisposition to disease; breast; epidermal growth factor receptor 2; tumor markers, biological; risk factors; breast neoplasms; brca1 protein; brca2 protein; survivin; uvomorulin; biopsy; cancer hormone therapy; disease progression; cancer size; partial mastectomy; predictive value of tests; cell polarity; invasive carcinoma; cyclin b1; cytokeratin 7; cytokeratin 19; cytokeratin 5; cytokeratin 6; progesterone receptor; genetic techniques; intraductal carcinoma; carcinoma, intraductal, noninfiltrating; lobular carcinoma in situ; cytokeratin 18; cytokeratin 8; glutathione transferase m1; nucleolus; intrinsic subtypes; immunoperoxidase staining
Journal Title: Advances in Anatomic Pathology
Volume: 20
Issue: 4
ISSN: 1072-4109
Publisher: Lippincott Williams & Wilkins  
Date Published: 2013-07-01
Start Page: 205
End Page: 216
Language: English
DOI: 10.1097/PAP.0b013e3182976ed5
PROVIDER: scopus
PUBMED: 23752083
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84880181027&partnerID=40&md5=6b4315d480f289121d2fba0a4c7532de
Notes: --- - "Export Date: 1 August 2013" - "Source: Scopus"
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MSK Authors
  1. Hannah Yong Wen
    305 Wen
  2. Edi Brogi
    520 Brogi
  3. Dara Stacy Ross
    149 Ross
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