Cryptococcal meningitis: Outcome in patients with AIDS and patients with neoplastic disease Journal Article

  


Authors: White, M.; Cirrincione, C.; Blevins, A.; Armstrong, D.
Article Title: Cryptococcal meningitis: Outcome in patients with AIDS and patients with neoplastic disease
Abstract: A retrospective analysis of 41 patients with cryptococcal meningitis and AIDS or neoplastic disease was done. Patients with AIDS were younger and predominantly male; they had a shorter duration of prior illness, higher initial serum cryptococcal antigen titers, and lower initial cerebro-spinal fluid white blood cell counts than those with neoplastic disease. The median overall survival for patients with AIDS was 9 months compared with 2 months for those with neoplastic disease (P =.004). Seventy-eight percent of patients with AIDS and 43% of those with neoplastic disease were cured or improved 6 months after diagnosis (P =.039). Toxicity from amphotericin B and flucytosine was similar for both groups. One patient with AIDS relapsed. Multivariate predictors of survival included headache (P =.007) and an AIDS diagnosis (P =.009). Examination of outcomes for other opportunistic infections associated with AIDS and other immunosup-pressive illnesses may distinguish prognostic features for different patient populations. © 1992 The University of Chicago.
Keywords: adult; clinical article; treatment outcome; aged; retrospective studies; disease course; conference paper; follow-up studies; neoplasm; neoplasms; retrospective study; survival time; drug therapy, combination; acquired immune deficiency syndrome; acquired immunodeficiency syndrome; meningitis; antifungal agents; opportunistic infections; cerebrospinal fluid cytology; flucytosine; middle age; amphotericin b; cryptococcus neoformans; amphotericin; prognosis; human; male; female; priority journal; support, u.s. gov't, p.h.s.; meningitis, cryptococcal
Journal Title: Journal of Infectious Diseases
Volume: 165
Issue: 5
ISSN: 0022-1899
Publisher: Oxford University Press  
Date Published: 1992-05-01
Start Page: 960
End Page: 963
Language: English
DOI: 10.1093/infdis/165.5.960
PUBMED: 1569350
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0026606053&doi=10.1093%2finfdis%2f165.5.960&partnerID=40&md5=0b8f741f01469ad29c77232dbeaa11e0
Notes: Article -- Source: Scopus
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MSK Authors
  1. Mary H White
    44 White
  2. Donald Armstrong
    242 Armstrong
  3. Constance Cirrincione
    21 Cirrincione
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