Pneumocystis carinii pneumonia in patients without AIDS Conference Paper


Author: Sepkowitz, K. A.
Title: Pneumocystis carinii pneumonia in patients without AIDS
Conference Title: Controversies in the Management of Infections in Immunocompromised Patients - Symposium
Abstract: In the 1980s, tens of thousands of cases of Pneumocystis carinii pneumonia (PCP) occurred in persons with AIDS, making it the most common opportunistic infection encountered in this patient population. Thus, the presentation and clinical course of PCP became well-known to many physicians. Overshadowed by this epidemic was the continued occurrence of PCP in persons not infected with the human immunodeficiency virus, most notably those receiving immuno-suppressive therapy for neoplastic disease or other indications. A review from Memorial Sloan-Kettering Cancer Center has demonstrated that, in addition to those patients previously defined as at risk—those with acute lymphocytic leukemia or allogeneic bone marrow transplantation—patients receiving corticosteroid therapy for a primary or metastatic brain neoplasm are at risk for PCP and should receive prophylaxis. Among patients with neoplastic disease, the disease may be more fulminant and the mortality rate higher—approaching 50% in most series. Wider use of prophylaxis should decrease the frequency of this disease, while prompt initiation of therapy in patients with a compatible syndrome should help to lower mortality rates. © 1993 by The University of Chicago.
Keywords: mortality; fluorouracil; conference paper; cytarabine; methotrexate; disease association; risk factors; allogenic bone marrow transplantation; pneumocystis pneumonia; primaquine; time factors; folinic acid; dactinomycin; asparaginase; bleomycin; new york city; brain cancer; acquired immune deficiency syndrome; acute lymphocytic leukemia; infection prevention; corticosteroid; cyclosporin a; bone marrow transplantation; cotrimoxazole; atovaquone; dapsone; pentamidine; infection risk; deferoxamine; clindamycin; sulfamethoxazole; trimethoprim; trimetrexate; adrenal cortex hormones; virus culture; leukemia, lymphocytic; human; priority journal; pneumonia, pneumocystis carinii
Journal Title Clinical Infectious Diseases
Volume: 17
Issue: Suppl. 2
Conference Dates: 1992 Nov 18-20
Conference Location: New York, NY
ISBN: 1058-4838
Publisher: Oxford University Press  
Date Published: 1993-11-01
Start Page: S416
End Page: S422
Language: English
DOI: 10.1093/clinids/17.Supplement_2.S416
PUBMED: 8274607
PROVIDER: scopus
DOI/URL:
Notes: Source: Scopus
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  1. Kent A Sepkowitz
    270 Sepkowitz
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