The adenoma carcinoma sequence in colorectal neoplasia Journal Article


Authors: Paty, P. B.; Cohen, A. M.
Article Title: The adenoma carcinoma sequence in colorectal neoplasia
Abstract: Knowledge of the biological events involved in colorectal tumor formation is progressing rapidly. Molecular studies support the clinical impression that adenocarcinoma of the large intestine develops in stages. At the center of the pathological continuum between normal mucosa and invasive carcinoma is the premalignant lesion, the adenomatous polyp. We review the epidemiological, morphological, biochemical, and genetic evidence implicating adenomas as precursors of colorectal carcinoma. The molecular changes most highly implicated in neoplastic initiation and progression are reviewed in detail. Current strategies of chemoprevention are summarized, and future prospects for clinical intervention are outlined.
Keywords: adolescent; adult; aged; middle aged; review; adenocarcinoma; proto oncogene; colorectal neoplasms; tumor suppressor gene; adenoma; colorectal tumor; colon polyp; colonic polyps; genes, tumor suppressor; adenomatous polyp; proto-oncogenes; adenomatous polyposis coli; adenomatous polyps; colon polyposis; humans; human; male; female
Journal Title: The Gastroenterologist
Volume: 1
Issue: 4
ISSN: 1065-2477
Publisher: Little, Brown & Co  
Date Published: 1993-12-01
Start Page: 274
End Page: 286
Language: English
PUBMED: 8055224
PROVIDER: scopus
DOI/URL:
Notes: Source: Scopus
Citation Impact
MSK Authors
  1. Philip B Paty
    410 Paty
  2. Alfred M Cohen
    241 Cohen