Evolving treatment of advanced colorectal cancer Journal Article
| Authors: | Cercek, A.; Saltz, L. |
| Article Title: | Evolving treatment of advanced colorectal cancer |
| Abstract: | Advances in colorectal cancer treatment have led to improved outcomes for patients. A number of cytotoxic agents, alone and in combination, have shown activity. The addition of the newer, so-called "targeted" agents to standard chemotherapy drugs and regimens has also modestly improved outcomes. Progress in our knowledge and understanding of molecular pathways has led to the identification of markers critical in determining response or nonresponse to some of the targeted agents. This review discusses the available therapies in metastatic colorectal cancer and describes some of the molecular markers implicated in activity and resistance to current targeted therapies. © 2010 Springer Science+Business Media, LLC. |
| Keywords: | cancer survival; treatment response; overall survival; clinical trial; neutropenia; review; bevacizumab; cytotoxic agent; fluorouracil; placebo; sunitinib; advanced cancer; cancer combination chemotherapy; cancer growth; diarrhea; drug efficacy; drug potentiation; drug safety; hypertension; skin toxicity; treatment duration; antineoplastic agents; capecitabine; cancer staging; drug megadose; neurotoxicity; antineoplastic agent; mutant protein; colorectal cancer; cancer immunotherapy; metastasis; progression free survival; infection; leukopenia; mucosa inflammation; nausea; vomiting; neoplasm proteins; vasculotropin inhibitor; wild type; cetuximab; phosphatidylinositol 3 kinase; tumor marker; prediction; irinotecan; panitumumab; rash; colorectal neoplasms; molecular marker; drug fatality; folinic acid; kras; cancer control; oxaliplatin; k ras protein; alopecia; vasculotropin antibody; b raf kinase; braf; epidermal growth factor receptor antibody; artery thrombosis; drug dose sequence; folfiri; folfox |
| Journal Title: | Current Oncology Reports |
| Volume: | 12 |
| Issue: | 3 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2010-05-01 |
| Start Page: | 153 |
| End Page: | 159 |
| Language: | English |
| DOI: | 10.1007/s11912-010-0096-1 |
| PUBMED: | 20425074 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 2" - "Export Date: 20 April 2011" - "CODEN: CORUA" - "Source: Scopus" |
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