Targeted therapy for metastatic colorectal cancer: Current challenges and future directions Journal Article
| Authors: | Reidy, D.; Saltz, L. |
| Article Title: | Targeted therapy for metastatic colorectal cancer: Current challenges and future directions |
| Abstract: | Progress in understanding tumor biology has led to the identification of a number of candidate molecules that are potential targets for the medical treatment of cancer. Drugs that impede these molecules are labeled targeted therapies. The goal of these drugs is to selectively interrupt the molecular pathways responsible for tumor growth and survival. Some of these targeted therapies have made important, albeit modest, contributions to the treatment of patients with metastatic colorectal cancer. It is becoming apparent, however, that the activity levels with the currently available targeted therapies are far lower than hoped, and toxici-ties are often nontrivial. In this review, we first discuss the data regarding these agents and the challenges of optimizing targeted therapies through combinations with cytotoxic chemotherapies and combinations of multiple targeted agents. We also focus on some of the newer promising drugs and strategies currently being tested in clinical trials. Copyright © 2008 by Current Medicine Group LLC. |
| Journal Title: | Current Colorectal Cancer Reports |
| Volume: | 3 |
| Issue: | 3 |
| ISSN: | 1556-3790 |
| Publisher: | Springer |
| Date Published: | 2007-01-01 |
| Start Page: | 109 |
| End Page: | 115 |
| Language: | English |
| DOI: | 10.1007/s11888-007-0018-2 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 March 2013" - "Source: Scopus" |
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