First-line treatment of patients with metastatic colorectal cancer: An overview of recent data on chemotherapy plus targeted agents Journal Article
| Authors: | Cercek, A.; Saltz, L. B. |
| Article Title: | First-line treatment of patients with metastatic colorectal cancer: An overview of recent data on chemotherapy plus targeted agents |
| Abstract: | Colorectal cancer (CRC) is the second leading cause of cancer-related death in the United States. Advances in therapies over the past decade have led to improved outcomes for many patients. In addition to cytotoxic chemotherapy, advances in our understanding of tumor biology have led to the development of agents targeted against molecular pathways. The addition of these so-called targeted agents has been shown to add further to the activity of chemotherapy combinations and, in some cases, to offer modest survival advantages. However, these agents are not without substantial potential for toxicity. This review will discuss the available therapies and the data to justify the appropriate use and nonuse of targeted therapies in patients with metastatic CRC. |
| Keywords: | vasculotropin; cancer survival; treatment outcome; treatment response; vascular endothelial growth factor a; clinical trial; fatigue; neutropenia; review; bevacizumab; fluorouracil; cancer combination chemotherapy; diarrhea; drug efficacy; drug safety; drug withdrawal; hypertension; monotherapy; antineoplastic agents; clinical trials as topic; capecitabine; antineoplastic agent; colorectal cancer; metastasis; bleeding; leukopenia; nausea; neuropathy; thrombocytopenia; antineoplastic combined chemotherapy protocols; epidermal growth factor receptor; receptor, epidermal growth factor; antineoplastic activity; pathology; cetuximab; irinotecan; monoclonal antibody; panitumumab; rash; drug delivery systems; colorectal neoplasms; antibodies, monoclonal; drug antagonism; thromboembolism; colorectal tumor; folinic acid; vasculotropin a; genes, ras; oxaliplatin; k ras protein; alopecia; digestive system perforation; oncogene ras; artery thrombosis; drug delivery system; k-ras; folfiri; folfox |
| Journal Title: | Clinical Colorectal Cancer |
| Volume: | 7 |
| Issue: | Suppl. 2 |
| ISSN: | 1533-0028 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2008-12-01 |
| Start Page: | S47 |
| End Page: | S51 |
| Language: | English |
| DOI: | 10.3816/CCC.2008.s.007 |
| PUBMED: | 19064406 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 4" - "Export Date: 17 November 2011" - "CODEN: CCCLC" - "Source: Scopus" |
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