Management of metastatic colorectal cancer: The impact of clinical trials reported at ASCO 2007 Journal Article

  


Author: Saltz, L.
Article Title: Management of metastatic colorectal cancer: The impact of clinical trials reported at ASCO 2007
Abstract: Chemotherapy is the fundamental intervention for palliation of patients with metastatic colorectal cancer (mCRC). Chemotherapy regimens incorporating a fluoropyrimidine with irinotecan or oxaliplatin and the biologic agents bevacizumab, cetuximab, and panitumumab have improved treatment outcomes, achieving a median overall survival in mCRC patients that approaches 24 months. However, controversies abound regarding regimen selection, schedule of administration, treatment toxicity, the role of sequential versus combination therapy, and the most appropriate strategy for utilization of newer, targeted biologic agents. The latest findings from trials evaluating potential advances in the therapy of mCRC were presented at the 43rd Annual Meeting of the American Society of Clinical Oncology (ASCO) in 2007. Their impact on clinical practice is reviewed and evaluated here. © 2008 Elsevier Inc. All rights reserved.
Keywords: vasculotropin; cancer chemotherapy; cancer survival; treatment outcome; cancer surgery; survival rate; overall survival; clinical trial; disease course; review; cancer recurrence; bevacizumab; fluorouracil; cancer growth; drug efficacy; drug safety; treatment planning; unspecified side effect; capecitabine; cancer staging; neurotoxicity; outcome assessment; follow up; clinical practice; colorectal cancer; treatment indication; metastasis; apoptosis; cell growth; palliative therapy; epidermal growth factor receptor; combination chemotherapy; cetuximab; cancer research; irinotecan; panitumumab; drug receptor binding; injection site reaction; rash; survival time; disease severity; folinic acid; cancer cell; medical society; protein secretion; cancer registry; drug blood level; cross reaction; oxaliplatin; fluoropyrimidine; hypersensitivity reaction; immunoglobulin e
Journal Title: Community Oncology
Volume: 5
Issue: 1
ISSN: 1548-5315
Publisher: Elsevier Inc.  
Date Published: 2008-01-01
Start Page: 37
End Page: 42
Language: English
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-38949110269&partnerID=40&md5=0826317f3c56b07edbcddde1074a2f79
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 17 November 2011" - "Source: Scopus"