Clinical characterization of human metapneumovirus infection among patients with cancer Journal Article
| Authors: | Kamboj, M.; Gerbin, M.; Huang, C. K.; Brennan, C.; Stiles, J.; Balashov, S.; Park, S.; Kiehn, T. E.; Perlin, D. S.; Pamer, E. G.; Sepkowitz, K. A. |
| Article Title: | Clinical characterization of human metapneumovirus infection among patients with cancer |
| Abstract: | Background: Human metapneumovirus is a recently discovered RNA virus that typically causes respiratory disease in children. It has been linked to severe lower airway disease in hematopoietic stem cell and solid-organ transplant recipients. hMPV infection in a large population of patients with underlying cancer and varying degrees of immunosuppression has not been reported. We sought to characterize hMPV infection in patients with cancer. Methods: Review of all cases of hMPV infection from two seasons (2005-6 and 2006-7) detected by DFA and/or real-time PCR at MSKCC, a tertiary cancer center in New York City. Results: Among MSKCC patients with cancer, 51 (2.7%) of 1899 patients were positive for hMPV, including 3.2% with hematologic neoplasm and 1.7% with solid tumors. More children (4.5%) were positive than adults (2.2%). PCR detected twice as many cases as DFA. Cough and fever were common complaints. The longest shedding period was 80 days. 40 patients received radiographic evaluation; of these, 22 showed abnormalities including patchy (11), ground glass (5), and interstitial infiltrates (4). Conclusions: hMPV causes a nonspecific respiratory illness and was found in more than 2% of all tested persons with cancer. PCR detected substantially more cases than DFA. Unlike previous reports, we observed no fatalities due to hMPV, including 22 HSCT recipients with the infection. © 2008 The British Infection Society. |
| Keywords: | adolescent; adult; child; controlled study; human tissue; child, preschool; retrospective studies; acute granulocytic leukemia; major clinical study; solid tumor; united states; cancer patient; antineoplastic agent; neoplasms; infection; prevalence; immunoglobulin; hematopoietic stem cell transplantation; chronic myeloid leukemia; risk factor; hodgkin disease; age; coughing; fever; fluorescent antibody technique; hematologic malignancy; infant; reverse transcriptase polymerase chain reaction; nucleotide sequence; graft versus host reaction; new york city; fluorescent antibody technique, direct; thorax radiography; urogenital tract tumor; real time polymerase chain reaction; acute lymphocytic leukemia; corticosteroid; ribavirin; infection risk; graft recipient; lung infiltrate; viral respiratory tract infection; virus transmission; rna, viral; fatality; antigens, viral; respiratory tract infections; human metapneumovirus; virus shedding; metapneumovirus; paramyxoviridae infections |
| Journal Title: | Journal of Infection |
| Volume: | 57 |
| Issue: | 6 |
| ISSN: | 0163-4453 |
| Publisher: | W.B. Saunders Co. |
| Date Published: | 2008-12-01 |
| Start Page: | 464 |
| End Page: | 471 |
| Language: | English |
| DOI: | 10.1016/j.jinf.2008.10.003 |
| PUBMED: | 19027169 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 11" - "Export Date: 17 November 2011" - "CODEN: JINFD" - "Molecular Sequence Numbers: GENBANK: AF371337, AY525843;" - "Source: Scopus" |
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