2009 H1N1 influenza infection in cancer patients and hematopoietic stem cell transplant recipients Journal Article
| Authors: | Redelman-Sidi, G.; Sepkowitz, K. A.; Huang, C. K.; Park, S.; Stiles, J.; Eagan, J.; Perlin, D. S.; Pamer, E. G.; Kamboj, M. |
| Article Title: | 2009 H1N1 influenza infection in cancer patients and hematopoietic stem cell transplant recipients |
| Abstract: | OBJECTIVES: Although usually mild, 2009 H1N1 Influenza has caused up to 6000 deaths in the US. To determine outcome in patients with cancer and/or hematopoietic stem cell transplant (HSCT), we reviewed our recent experience at Memorial Sloan-Kettering Cancer Center (MSKCC). METHODS: During the initial NYC outbreak (May 19-June 30, 2009), all respiratory samples at MSKCC were tested for 2009 H1N1 influenza by DFA, culture, and RT-PCR. Medical records were reviewed for all cases. RESULTS: During the 6-week period, 45(11%) of 394 tested patients were diagnosed with 2009 H1N1 Influenza. These included 29(17%) of 167 patients with hematologic conditions compared to 16(7%) of 226 with solid tumors (P < 0.01). 21(22%) of 96 tested HSCT recipients were positive. Cough (93%) and fever (91%) were common. Of 29 patients who were radiographically assessed, 8(27%) had lower airway disease. 17(37%) were hospitalized. None required mechanical ventilation. No deaths were attributed to influenza. All treated patients tolerated antiviral medication. CONCLUSIONS: 2009 H1N1 Influenza caused mild symptoms in most patients with cancer and/or HSCT. None died or required mechanical ventilation. Immunosuppression from cancer or its treatment including HSCT may not be a substantial risk for poor outcome, however further studies are needed to validate our results. Copyright 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved. |
| Keywords: | adolescent; adult; child; preschool child; aged; aged, 80 and over; child, preschool; middle aged; young adult; mortality; united states; neoplasm; neoplasms; hematopoietic stem cell transplantation; pathology; virology; immunocompromised host; isolation and purification; influenza; influenza, human; immunocompromised patient; influenza virus a h1n1; influenza a virus, h1n1 subtype |
| Journal Title: | Journal of Infection |
| Volume: | 60 |
| Issue: | 4 |
| ISSN: | 0163-4453 |
| Publisher: | W.B. Saunders Co. |
| Date Published: | 2010-04-01 |
| Start Page: | 257 |
| End Page: | 263 |
| Language: | English |
| PUBMED: | 20138188 |
| PROVIDER: | scopus |
| DOI: | 10.1016/j.jinf.2010.01.009 |
| DOI/URL: | |
| Notes: | - "Source: Scopus" |
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