Detection of premalignant gastrointestinal lesions using surface-enhanced resonance Raman scattering-nanoparticle endoscopy Journal Article

   

Authors:	Harmsen, S.; Rogalla, S.; Huang, R.; Spaliviero, M.; Neuschmelting, V.; Hayakawa, Y.; Lee, Y.; Tailor, Y.; Toledo-Crow, R.; Kang, J. W.; Samii, J. M.; Karabeber, H.; Davis, R. M.; White, J. R.; van de Rijn, M.; Gambhir, S. S.; Contag, C. H.; Wang, T. C.; Kircher, M. F.
Article Title:	Detection of premalignant gastrointestinal lesions using surface-enhanced resonance Raman scattering-nanoparticle endoscopy
Abstract:	Cancers of the gastrointestinal (GI) tract are among the most frequent and most lethal cancers worldwide. An important reason for this high mortality is that early disease is typically asymptomatic, and patients often present with advanced, incurable disease. Even in high-risk patients who routinely undergo endoscopic screening, lesions can be missed due to their small size or subtle appearance. Thus, current imaging approaches lack the sensitivity and specificity to accurately detect incipient GI tract cancers. Here we report our finding that a single dose of a high-sensitivity surface-enhanced resonance Raman scattering nanoparticle (SERRS-NP) enables reliable detection of precancerous GI lesions in animal models that closely mimic disease development in humans. Some of these animal models have not been used previously to evaluate imaging probes for early cancer detection. The studies were performed using a commercial Raman imaging system, a newly developed mouse Raman endoscope, and finally a clinically applicable Raman endoscope for larger animal studies. We show that this SERRS-NP-based approach enables robust detection of small, premalignant lesions in animal models that faithfully recapitulate human esophageal, gastric, and colorectal tumorigenesis. This method holds promise for much earlier detection of GI cancers than currently possible and could lead therefore to marked reduction of morbidity and mortality of these tumor types. © 2019 American Chemical Society.
Keywords:	sensitivity and specificity; animals; nanoparticles; nanoparticle; gastrointestinal tract; endoscopy; diseases; early detection; chemical detection; cancer; raman; preclinical; raman scattering; surface scattering; surface-enhanced resonance raman scattering; early cancer detection; nanometals; gastrointestinal lesions
Journal Title:	ACS Nano
Volume:	13
Issue:	2
ISSN:	1936-0851
Publisher:	American Chemical Society
Date Published:	2019-02-26
Start Page:	1354
End Page:	1364
Language:	English
DOI:	10.1021/acsnano.8b06808
PROVIDER:	scopus
PUBMED:	30624916
PMCID:	PMC6428194
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85061250412&doi=10.1021%2facsnano.8b06808&partnerID=40&md5=b40c116d0f54ad2072d427a7395e6d08
Notes:	Article -- Export Date: 1 March 2019 -- Source: Scopus

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