The advantage of rearranging bcl-6 - To the editor Journal Article
| Authors: | Offit, K.; Chaganti, R. S. K. |
| Article Title: | The advantage of rearranging bcl-6 - To the editor |
| Abstract: | To the Editor: In his editorial on the article by Offit and colleagues (July 14 issue),1 Kluin2 concludes that “it is intriguing that activation of the bcl-6 gene seems to be disadvantageous to lymphoma cells: movement of the gene to a new chromosome apparently curtails the malignant behavior of the tumor.” Kluin confronts us with a riddle, because it is difficult to see how any disadvantageous mutation in a malignant cell could lead to a clonal overgrowth of that cell and its progeny. There is no need to conclude that bcl-6 “curtails the malignant behavior of the tumor.” Genotypically, diffuse... © 1994, Massachusetts Medical Society. All rights reserved. |
| Keywords: | dna-binding proteins; proto-oncogene proteins; letter; transcription factors; cancer genetics; gene rearrangement; lymphoma; genetic damage; lymphoma, large-cell, diffuse; human; priority journal |
| Journal Title: | New England Journal of Medicine |
| Volume: | 331 |
| Issue: | 21 |
| ISSN: | 0028-4793 |
| Publisher: | Massachusetts Medical Society |
| Date Published: | 1994-11-24 |
| Start Page: | 1460 |
| Language: | English |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | For full correspondence, see DOI: 10.1056/nejm199411243312118 -- For original article, see PMID: 8208254, DOI: 10.1056/NEJM199407143310210 -- Source: Scopus |
