Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma Journal Article
| Authors: | Ye, B. H.; Lista, F.; Lo Coco, F.; Knowles, D. M.; Offit, K.; Chaganti, R. S. K.; Dalla-Favera, R. |
| Article Title: | Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma |
| Abstract: | The molecular pathogenesis of diffuse large-cell lymphoma (DLCL), the most frequent and clinically relevant type of lymphoma, is unknown. A gene was cloned from chromosomal translocations affecting band 3q27, which are common in DLCL. This gene, BCL-6, codes for a 79-kilodalton protein that is homologous with zinc finger-transcription factors. In 33 percent (13 of 39) of DLCL samples, but not in other types of lymphoid malignancies, the BCL-6 gene is truncated within its 5′ noncoding sequences, suggesting that its expression is deregulated. Thus, BCL-6 may be a proto-oncogene specifically involved in the pathogenesis of DLCL. |
| Keywords: | clinical article; dna-binding proteins; exons; proto-oncogene proteins; cell line; introns; transcription factor; transcription factors; molecular cloning; gene rearrangement; amino acid sequence; molecular sequence data; sequence homology, amino acid; lymphoma; chromosome translocation; zinc finger protein; chromosome 3q; dna, complementary; chromosomes, human, pair 3; zinc fingers; proto-oncogenes; lymphoma, large-cell, diffuse; human; priority journal; article; support, non-u.s. gov't; support, u.s. gov't, p.h.s.; translocation (genetics) |
| Journal Title: | Science |
| Volume: | 262 |
| Issue: | 5134 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 1993-10-29 |
| Start Page: | 747 |
| End Page: | 750 |
| Language: | English |
| DOI: | 10.1126/science.8235596 |
| PUBMED: | 8235596 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2019 -- Source: Scopus |
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