Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma Journal Article

   


Authors: Migliazza, A.; Martinotti, S.; Chen, W.; Fusco, C.; Ye, B.; Knowles, D. M.; Offit, K.; Chaganti, R. S. K.; Dalla-Favera, R.
Article Title: Frequent somatic hypermutation of the 5′ noncoding region of the BCL6 gene in B-cell lymphoma
Abstract: The BCL6 gene encodes a zinc-finger transcription factor and is altered by chromosomal rearrangements in its 5′ noncoding region in ≈30% of diffuse large-cell lymphoma (DLCL). We report here that, in 22/30 (73%) DLCL and 7/15 (47%) follicular lymphoma (FL), but not in other tumor types, the BCL6 gene is also altered by multiple (1.4 × 10-3-1.6 × 10-2 per bp), often biallelic, mutations clustering in its 5′ noncoding region. These mutations are of somatic origin and are found in cases displaying either normal or rearranged BCL6 alleles indicating their independence from chromosomal rearrangements and linkage to immunoglobulin genes. These alterations identify a mechanism of genetic instability in malignant B cells and may have been selected during lymphomagenesis for their role in altering BCL6 expression.
Keywords: controlled study; human tissue; gene mutation; human cell; mutation; dna-binding proteins; proto-oncogene proteins; sequence deletion; polymerase chain reaction; alleles; gene frequency; transcription factors; b cell lymphoma; gene expression regulation, neoplastic; lymphoma, b-cell; gene rearrangement; molecular sequence data; genetic stability; base sequence; dna primers; point mutation; zinc fingers; proto-oncogenes; restriction mapping; polymorphism, single-stranded conformational; proto-oncogene proteins c-bcl-6; humans; human; priority journal; article
Journal Title: Proceedings of the National Academy of Sciences of the United States of America
Volume: 92
Issue: 26
ISSN: 0027-8424
Publisher: National Academy of Sciences  
Date Published: 1995-12-19
Start Page: 12520
End Page: 12524
Language: English
DOI: 10.1073/pnas.92.26.12520
PUBMED: 8618933
PROVIDER: scopus
PMCID: PMC40389
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029614378&doi=10.1073%2fpnas.92.26.12520&partnerID=40&md5=0a1149ad1f9dfbbdd725846d889f79d0
Notes: Article -- Export Date: 28 August 2018 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Kenneth Offit
    788 Offit
  2. Weiyi Chen
    20 Chen
  3. Raju S K Chaganti
    391 Chaganti
Related MSK Work