The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation Journal Article

  

Authors:	Kolesnick, R. N.; Haimovitz-Friedman, A.; Fuks, Z.
Article Title:	The sphingomyelin signal transduction pathway mediates apoptosis for tumor necrosis factor, Fas, and ionizing radiation
Abstract:	Recent evidence suggests that tumor necrosis factor alpha, Fas, and ionizing radiation employ the sphingomyelin pathway to trigger apoptosis. The sphingomyelin pathway is initiated by hydrolysis of plasma membrane sphingomyelin to generate ceramide via a sphingomyelinase. Ceramide serves as a second messenger stimulating a cascade of kinases and transcription factors that activate a final common pathway of programmed cell death. The extent to which this signaling system is used in apoptosis induced by other toxic modalities is not known, but accumulating evidence suggests that it is a commonly employed pathway that could be exploited therapeutically.
Keywords:	signal transduction; review; animal; animals; apoptosis; fas antigen; radiation exposure; physiology; membrane antigen; tumor necrosis factor alpha; tumor necrosis factor-alpha; antigens, surface; sphingomyelin; second messenger; antigens, cd95; second messenger systems; sphingomyelins; humans; human
Journal Title:	Biochemistry and Cell Biology
Volume:	72
Issue:	11-12
ISSN:	0829-8211
Publisher:	Canadian Science Publishing
Date Published:	1994-11-01
Start Page:	471
End Page:	474
Language:	English
DOI:	10.1139/o94-063
PUBMED:	7544586
PROVIDER:	scopus
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028537064&doi=10.1139%2fo94-063&partnerID=40&md5=ef6ca9816fe468647ff46efd3dab952e
Notes:	Review -- Export Date: 1 February 2019 -- Source: Scopus

https://synapse.mskcc.org/synapse/works/has_related_data_chk/140083