Alternative miRNA Biogenesis Pathways and the Interpretation of Core miRNA Pathway Mutants Journal Article

   

Authors:	Yang, J. S.; Lai, E.
Article Title:	Alternative miRNA Biogenesis Pathways and the Interpretation of Core miRNA Pathway Mutants
Abstract:	Since the establishment of a canonical animal microRNA biogenesis pathway driven by the RNase III enzymes Drosha and Dicer, an unexpected variety of alternative mechanisms that generate functional microRNAs have emerged. We review here the many Drosha-independent and Dicer-independent microRNA biogenesis strategies characterized over the past few years. Beyond reflecting the flexibility of small RNA machineries, the existence of noncanonical pathways has consequences for interpreting mutants in the core microRNA machinery. Such mutants are commonly used to assess the consequences of "total" microRNA loss, and indeed, they exhibit many overall phenotypic similarities. Nevertheless, ongoing studies reveal a growing number of settings in which alternative microRNA pathways contribute to distinct phenotypes among core microRNA biogenesis mutants. © 2011 Elsevier Inc.
Keywords:	controlled study; unclassified drug; mutation; review; nonhuman; oocyte; phenotype; animals; microrna; gene expression; genotype; drosophila; animalia; gene expression regulation; rna-binding proteins; rna, messenger; gene loss; gene control; models, genetic; transfer rna; micrornas; rna processing; nervous system development; argonaute protein; drosophila proteins; rna-induced silencing complex; short hairpin rna; rna cleavage; rna splicing; mutant; biogenesis; dicer; double stranded rna; ribonuclease iii; knockout gene; eukaryotic initiation factors; olfactory system; drosha; olfactory pathways
Journal Title:	Molecular Cell
Volume:	43
Issue:	6
ISSN:	1097-2765
Publisher:	Cell Press
Date Published:	2011-09-16
Start Page:	892
End Page:	903
Language:	English
DOI:	10.1016/j.molcel.2011.07.024
PROVIDER:	scopus
PMCID:	PMC3176435
PUBMED:	21925378
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-80052996141&partnerID=40&md5=22da359e5520004bf72f82b9d559a0a7
Notes:	--- - "Cited By (since 1996): 1" - "Export Date: 2 November 2011" - "CODEN: MOCEF" - "Source: Scopus"

https://synapse.mskcc.org/synapse/works/has_related_data_chk/13643