Mirtrons: MicroRNA biogenesis via splicing Journal Article


Authors: Westholm, J. O.; Lai, E. C.
Article Title: Mirtrons: MicroRNA biogenesis via splicing
Abstract: A well-defined mechanism governs the maturation of most microRNAs (miRNAs) in animals, via stepwise cleavage of precursor hairpin transcripts by the Drosha and Dicer RNase III enzymes. Recently, several alternative miRNA biogenesis pathways were elucidated, the most prominent of which substitutes Drosha cleavage with splicing. Such short hairpin introns are known as mirtrons, and their study has uncovered related pathways that combine splicing with other ribonucleolytic machinery to yield Dicer substrates for miRNA biogenesis. In this review, we consider the mechanisms of splicing-mediated miRNA biogenesis, computational strategies for mirtron discovery, and the evolutionary implications of the existence of multiple miRNA biogenesis pathways. Altogether, the features of mirtron pathways illustrate unexpected flexibility in combining RNA processing pathways, and highlight how multiple functions can be encoded by individual transcripts. © 2011 Elsevier Masson SAS. All rights reserved.
Keywords: single nucleotide polymorphism; review; nonhuman; animals; microrna; intron; introns; rna interference; evolution; animalia; evolution, molecular; molecular sequence data; mammal; base sequence; genome; fly; caenorhabditis elegans; drosophila melanogaster; worm; micrornas; rna, untranslated; rna processing; vertebrate; short hairpin rna; rna splicing; rna precursors; biogenesis; ribonuclease iii; rna processing, post-transcriptional; nematode; splicing; mirtron; small rna biogenesis; invertebrate
Journal Title: Biochimie
Volume: 93
Issue: 11
ISSN: 0300-9084
Publisher: Editions Scientifiques Elsevier  
Date Published: 2011-11-01
Start Page: 1897
End Page: 1904
Language: English
DOI: 10.1016/j.biochi.2011.06.017
PROVIDER: scopus
PMCID: PMC3185189
PUBMED: 21712066
DOI/URL:
Notes: --- - "Export Date: 2 November 2011" - "CODEN: BICMB" - "Source: Scopus"
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  1. Eric C Lai
    135 Lai